Successful Treatment of Primary Amoebic Meningoencephalitis Using a Novel Therapeutic Regimen Including Miltefosine and Voriconazole

被引：4

作者：

Martinez, Dalila Y. ^{[1
,2
]}

Bravo-Cossio, Fanny ^{[3
]}

del Carmen Valdivia-Tapia, Maria ^{[3
]}

Yhuri Carreazo, Nilton ^{[3
]}

Cabello-Vilchez, Alfonso M. ^{[1
,4
]}

机构：

[1] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander Von Humboldt, Lima, Peru

[2] Hosp Cayetano Heredia, Dept Enfermedades Infecciosas Trop & Dermatol, Lima, Peru

[3] Hosp Emergencias Pediat, Lima, Peru

[4] Univ Privada Norbert Wiener, Escuela Tecnol Med Lab Clin & Anat Patol, Lima, Peru

来源：

ACTA PARASITOLOGICA | 2022年 / 67卷 / 03期

关键词：

Naegleria; Central nervous system protozoal infections; Child; Miltefosine; Voriconazole; NAEGLERIA-FOWLERI; BALAMUTHIA-MANDRILLARIS; IN-VITRO; DIAGNOSIS; INFECTION;

D O I：

10.1007/s11686-022-00591-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The genus Naegleria consists of free-living amoebae widely distributed worldwide in soil and freshwater habitats. Primary amoebic meningoencephalitis (PAM) is an uncommon and most likely fatal disease. The incubation period is approximately 7 days. The first symptoms are headache, nasal congestion, fever, vomiting, stiff neck within 3-4 days after the first symptoms, confusion, abnormal behavior, seizures, loss of balance and body control, coma, and death. We describe the case of a child who presented with PAM due to Naegleria sp., fully recovered from the infection without apparent sequels after treatment with a regimen that included miltefosine and voriconazole.

引用

页码：1421 / 1424

页数：4

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