Intensive epidermal adsorption and specific venous deposition of carboxyl quantum dots in zebrafish early-life stages

被引：14
作者：
Chen, Li Qiang [1 ]
Ding, Cheng Zhi [1 ]
Ling, Jian [2 ]
机构：
[1] Yunnan Univ, Inst Int Rivers & Ecosecur, Yunnan Key Lab Int Rivers & Transboundary Ecosecu, Kunming 650091, Yunnan, Peoples R China
[2] Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
来源：
CHEMOSPHERE | 2017年 / 184卷
基金：
中国国家自然科学基金;
关键词：
Biodistribution; Carboxyl-QDs; Cardiovascular system; Zebrafish; Fluorescence imaging; IN-VIVO; SILVER NANOPARTICLES; DANIO-RERIO; NANOTOXICITY ASSESSMENT; PHYSIOLOGICAL BEHAVIOR; SURFACE-CHEMISTRY; TOXICITY; EMBRYOS; TISSUE; CELLS;
D O I：
10.1016/j.chemosphere.2017.05.173
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
To properly assess the environmental risk of quantum dots (QDs), it is necessary to determine their fate in living organisms, including adsorption, distribution and bioaccumulation under representative environmental or physiological conditions. We comprehensively investigated the fate of QDs with carboxyl terminal functional groups (carboxyl-QDs) in zebrafish (Danio rerio) embryo and larvae subjected to either waterborne exposure or cardiovascular system microinjection. On waterborne exposure, carboxyl-QDs exhibited an intensive adsorption and accumulation in the chorion of embryos, and their predominate target organs were the gill and intestinal tract in larvae. On microinjection, carboxyl-QDs were rapidly delivered into the cardiovascular system and specifically deposited in veins and the capillary network system of zebrafish larvae, but not in the arterial system. Taken together, we found that the exact tissue condition including epidermal structures, mucus secretion and vascular microstructures strongly affected the adsorption, uptake and distribution of carboxyl-QDs in zebrafish. This work highlights the intensive tissue epidermal adsorption and accumulation of carboxyl-QDs and their specific vein and capillary deposition in the cardiovascular system in zebrafish early-life stages. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：44 / 52
页数：9
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