Cerebrospinal fluid insulin during non-neurological surgery

被引：23

作者：

Bromander, Sara ^{[1
]}

Anckarsater, Rolf ^{[1
]}

Ahren, Bo ^{[2
]}

Kristiansson, Marianne ^{[3
]}

Blennow, Kaj ^{[1
]}

Holmang, Agneta ^{[1
]}

Zetterberg, Henrik ^{[1
]}

Anckarsater, Henrik ^{[1
]}

Wass, Caroline E. ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden

[2] Lund Univ, Dept Clin Sci, Div Med, Lund, Sweden

[3] Karolinska Inst, Div Social & Forens Psychiat, Dept Clin Neurosci, Stockholm, Sweden

来源：

JOURNAL OF NEURAL TRANSMISSION | 2010年 / 117卷 / 10期

关键词：

Insulin; Cerebrospinal fluid; Surgical stress;

D O I：

10.1007/s00702-010-0456-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood-brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.

引用

页码：1167 / 1170

页数：4

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