The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations

被引：61

作者：

Keane, Michael ^{[1
]}

Craig, Thomas ^{[1
]}

Alfoeldi, Jessica ^{[2
]}

Berlin, Aaron M. ^{[2
]}

Johnson, Jeremy ^{[2
]}

Seluanov, Andrei ^{[3
]}

Gorbunova, Vera ^{[3
]}

Di Palma, Federica ^{[2
,4
]}

Lindblad-Toh, Kerstin ^{[2
,5
]}

Church, George M. ^{[6
]}

de Magalhaes, Joao Pedro ^{[1
]}

机构：

[1] Univ Liverpool, Inst Integrat Biol, Integrat Genom Ageing Grp, Liverpool L69 3BX, Merseyside, England

[2] Broad Inst MIT & Harvard, Cambridge, MA USA

[3] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

[4] Genome Anal Ctr, Norwich, Norfolk, England

[5] Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden

[6] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA

来源：

BIOINFORMATICS | 2014年 / 30卷 / 24期

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院; 英国惠康基金;

关键词：

P53 FUNCTIONAL DOMAIN; IDENTIFICATION; SUPPRESSION; RESISTANCE; INSIGHTS;

D O I：

10.1093/bioinformatics/btu579

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: The naked mole rat (Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent native to East Africa. Although its genome was previously sequenced, here we report a new assembly sequenced by us with substantially higher N50 values for scaffolds and contigs. Results: We analyzed the annotation of this new improved assembly and identified candidate genomic adaptations which may have contributed to the evolution of the naked mole rat's extraordinary traits, including in regions of p53, and the hyaluronan receptors CD44 and HMMR (RHAMM). Furthermore, we developed a freely available web portal, the Naked Mole Rat Genome Resource (http://www.nakedmole-rat.org), featuring the data and results of our analysis, to assist researchers interested in the genome and genes of the naked mole rat, and also to facilitate further studies on this fascinating species.

引用

页码：3558 / 3560

页数：3

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