Bronchoalveolar lavage neutrophilia in acute lung allograft rejection and lymphocytic bronchiolitis

被引：31

作者：

Vos, Robin ^{[2
]}

Vanaudenaerde, Bart M. ^{[2
]}

Verleden, Stijn E. ^{[2
]}

De Vleeschauwer, Stephanie I. ^{[2
]}

Willems-Widyastuti, Anna ^{[2
]}

Van Raemdonck, Dirk E. ^{[3
,4
]}

Dupont, Lieven J. ^{[2
,4
]}

Nawrot, Tim S. ^{[5
,6
]}

Verbeken, Erik K. ^{[7
]}

Verleden, Geert M. ^{[1
,2
,4
]}

机构：

[1] Univ Hosp Gasthuisberg, Lung Transplantat Unit, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Lab Pneumol, Louvain, Belgium

[3] Katholieke Univ Leuven, Lab Expt Thorac Surg, Louvain, Belgium

[4] Katholieke Univ Leuven, Lung Transplantat Unit, Louvain, Belgium

[5] Univ Hasselt, Ctr Environm Sci, Diepenbeek, Belgium

[6] Katholieke Univ Leuven, Sch Publ Hlth, Unit Lung Toxicol Occupat & Environm Med, Louvain, Belgium

[7] Katholieke Univ Leuven, Dept Histol, Louvain, Belgium

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2010年 / 29卷 / 11期

关键词：

acute rejection; biopsy; bronchoalveolar lavage; lung transplantation; lymphocytic bronchiolitis; neutrophils; ACUTE CELLULAR REJECTION; OBLITERANS SYNDROME; WORKING FORMULATION; PULMONARY ALLOGRAFT; RISK-FACTOR; TRANSPLANTATION; RECIPIENTS; BIOPSY; BRONCHITIS; REVISION;

D O I：

10.1016/j.healun.2010.05.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Acute cellular rejection and lymphocytic bronchiolitis can impair allograft function after lung transplant (LTx). Both may be refractory to corticosteroid treatment. We hypothesized that bronchoalveolar lavage (BAL) neutrophilia may be increased in either acute rejection or lymphocytic bronchiolitis or may increase with increasing histologic severity. METHODS: All consecutive BAL with subsequent transbronchial biopsy (TBB) specimens, performed in 339 LTx recipients from 2001 to 2008, were retrospectively analyzed. TBB specimens were classified according to histologic grade with analysis of BAL total cell count and cell differentials. RESULTS: The analysis included 768 TBB specimens. After adjustment for possible confounders, BAL total cell count significantly increased both with grade A or B severity (p < 0.0001). A higher A grade was characterized by a significant increase in BAL lymphocytosis and neutrophilia (p < 0.0001), whereas for higher B grades, only a more prominent BAL neutrophilia was seen (p < 0.0001). CONCLUSIONS: Higher grade A, but, particularly, higher grade B severity scores are characterized by increased BAL neutrophilia. J Heart Lung Transplant 2010;29:1259-69 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.

引用

页码：1259 / 1269

页数：11

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