Cross-linked branched polyethylenimine used as a nitric oxide donor for prolonged nitric oxide release

被引：11

作者：

Ji, Yujie ^{[1
]}

Li, Guowei ^{[1
]}

Zhang, Wu ^{[2
]}

Ma, Dong ^{[1
]}

Xue, Wei ^{[1
]}

机构：

[1] Jinan Univ, Dept Biomed Engn, Guangdong Higher Educ Inst, Key Lab Biomat, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Affiliated Hosp 1, Guangzhou 510632, Guangdong, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 81卷

基金：

中国国家自然科学基金;

关键词：

CPCS cross-linked bPEI; Nitric oxide; Antibacterial; CHITOSAN OLIGOSACCHARIDES; BIOMEDICAL APPLICATIONS; ANTIBACTERIAL AGENTS; SOL-GELS; IN-VIVO; DELIVERY; NANOPARTICLES; XEROGELS; MECHANISMS; DENDRIMERS;

D O I：

10.1016/j.msec.2017.08.037

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In order to prolong NO release and enhance the antibacterial effect, N-Carboxy propionyl chitosan sodium (CPCS) was cross-linked to branched polyethylenimine (bPEI) (CPCS-bPEI) and used as a NO donor. The CPCS-bPEI has been successfully synthesized at different molar ratios of CPCS to bPEI, followed with the reaction with NO gas under a parr high-pressure reactor to yield CPCS-bPEI-NO. Successful preparation of CPCS-bPEI-NO was confirmed by elemental analysis, FITR. and SEM. The effective release of NO was determined by in vitro release. The antibacterial assay showed that CPCS-bPEI-NO can effectively inhibit Gram-negative Escherichia coli (E. coil) and Gram-positive Staphylococcus aureus (S. aureus). We found that the NO loading amount and antibacterial effect can be adjusted by the molar ratio of CPCS to bPEI, and there was no significant toxicity of CPCS-bPEI-NO, suggesting that it may serve as an ideal antimicrobial agent.

引用

页码：492 / 499

页数：8

共 34 条

[1] The Release of Nitric Oxide from S-Nitrosothiols Promotes Angiogenesis [J].