Increased expression of PDGF-BB predicts metastasis and poor prognosis in ovarian cancer patients

被引：0

作者：

Song, Zhiwang ^{[1
]}

Gao, Yong ^{[1
]}

Ye, Xiaojuan ^{[1
]}

Zhang, Xia ^{[1
]}

Yang, Guang ^{[1
]}

Feng, Chan ^{[1
]}

Lu, Yonglin ^{[1
]}

Dong, Chunyan ^{[1
]}

机构：

[1] Tongji Univ, Breast Canc Ctr, Shanghai East Hosp, 150 Jimo Rd, Shanghai 200120, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2016年 / 9卷 / 05期

关键词：

Ovarian cancer; platelet-derived growth factor-BB (PDGF-BB); prognosis; biomarker; immunohistochemistry; GROWTH FACTOR-BB; CARCINOMA CELLS; BETA-CATENIN; OVEREXPRESSION; PROLIFERATION; RECEPTORS; VASCULATURE; MUTATIONS; INVASION; VEGF;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: Association of PDGF-BB expression with presence, development, metastasis and prognosis of ovarian cancer was investigated. Methods: 102 ovarian cancer-related cases with follow-up information were made into tissue microarrays according to the paired principle of cancer tissues and the adjacent tissues. Subsequently, the expression of PDGF-BB was detected with immunohistochemical analysis and SPSS software was finally utilized to analyze the relationships between experimental data and clinical indicatives. Results: Expression of PDGF-BB in ovarian cancer tissues were notably higher than their adjacent tissues (P<0.05) and showed significant positive correlation with lymph node metastasis (LNM) status (P = 0.002), latent distant metastasis status (P = 0.001) and FIGO histology grade (P = 0.016). Moreover, survival analysis indicated that PDGF-BB expression in cancer tissues, serving as an independent correlation factor, was significantly correlated with poor prognosis (P<0.05). Conclusions: PDGF-BB is a crucial biomarker that is closely related with prognosis of ovarian cancer and also a potential molecular target for evaluating the prognosis and treatment of ovarian cancer.

引用

页码：5487 / 5492

页数：6

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