Mammalian antimicrobial peptides

被引：0
|
作者：
Cipáková, I [1 ]
Hostinová, E [1 ]
机构：
[1] Slovak Acad Sci, Inst Mol Biol, SK-84551 Bratislava, Slovakia
来源：
BIOLOGIA | 2003年 / 58卷 / 03期
关键词：
antimicrobial peptides; defensin; cathelicidin; histatin; innate immunity; antibiotics; therapeutics;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Antimicrobial peptides play a significant role in innate and adaptive immunity, and are particularly important in the first line of defense against microbial invaders. These mostly cationic peptides have a broad-spectrum antimicrobial activity, kill invaders rapidly by interaction with the membrane, they are synergistic with endogenous antimicrobial proteins and classical antibiotics, neutralize endotoxins, and have multiple roles as immunomodulators. This review centers on antimicrobial peptides produced in mammals, summarizes their structural characteristics and classification, gene expression and biosynthesis, biological activities, and discusses their prospects for the anti-microbial therapy.
引用
收藏
页码：335 / 341
页数：7
相关论文
共 50 条
  • [11] Exploratory investigation on the antibacterial effect of antimicrobial peptides of four mammalian plasmas
    Elyass, Mona E.
    Mahdi, Ahmed A.
    Semeih, Alamelhuda E.
    Eltaib, Farag I.
    Attitalla, Idrerss H.
    MICROBIAL PATHOGENESIS, 2021, 156
  • [12] The influence of rough lipopolysaccharide structure on molecular interactions with mammalian antimicrobial peptides
    Bello, Gianluca
    Bodin, Alice
    Lawrence, M. Jayne
    Barlow, David
    Mason, A. James
    Barker, Robert D.
    Harvey, Richard D.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2016, 1858 (02): : 197 - 209
  • [13] Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes
    Levy, O
    JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (05) : 909 - 925
  • [14] Determinants of selectivity of cationic antimicrobial peptides for bacterial vs. mammalian membranes
    Deber, Charles M.
    Glukhov, Evgenia
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [15] Mammalian Antimicrobial Peptides: Promising Therapeutic Targets Against Infection and Chronic Inflammation
    Dutta, Pujarini
    Das, Santasabuj
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 16 (01) : 99 - 129
  • [16] Basis for selectivity of cationic antimicrobial peptides for bacterial vs. mammalian membranes
    Glukhov, E
    Deber, CM
    BIOPOLYMERS, 2005, 80 (04) : 486 - 486
  • [17] Leaflet by Leaflet Synergistic Effects of Antimicrobial Peptides on Bacterial and Mammalian Membrane Models
    Roy, Arpita
    Sarangi, Nirod Kumar
    Ghosh, Surajit
    Prabhakaran, Amrutha
    Keyes, Tia E.
    JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2023, 14 (16): : 3920 - 3928
  • [18] Mammalian C-terminal filaggrin-2 peptides are soil-bacteria-killing antimicrobial peptides
    Teders, K.
    Hansmann, B.
    Schroeder, J. M.
    EXPERIMENTAL DERMATOLOGY, 2014, 23 (03) : E9 - E9
  • [19] The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity
    Yang, D
    Chertov, O
    Oppenheim, JJ
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 58 (07) : 978 - 989
  • [20] The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity
    D. Yang
    O. Chertov
    J. J. Oppenheim
    Cellular and Molecular Life Sciences CMLS, 2001, 58 : 978 - 989
12345