Diversity and specificity in location-based signaling outputs of neuronal GPCRs

被引：7

作者：

Kumar, G. Aditya ^{[1
]}

Puthenveedu, Manojkumar A. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pharmacol, Ann Arbor, MI 48109 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2022年 / 76卷

基金：

美国国家科学基金会;

关键词：

GPCR trafficking; Spatial encoding; Localization; Spatiotemporal regulation; Microenvironment; ACTIVATED PROTEIN-KINASE; DELTA-OPIOID-RECEPTOR; REGULATORY SUBUNIT; COUPLED RECEPTORS; MU; TRAFFICKING; MECHANISMS; ISOFORMS; TARGETS; CELLS;

D O I：

10.1016/j.conb.2022.102601

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The common mechanisms by which members of the G protein???coupled receptor (GPCR) family respond to neuro-transmitters in the brain have been well studied. However, it is becoming increasingly clear that GPCRs show great diversity in their intracellular location, interacting partners and effectors, and signaling consequences. Here we will discuss recent studies on the diversity of location, effectors, and signaling of GPCRs, and how these could interact to generate specific spatiotemporal patterns of GPCR signaling in cells.

引用

页数：9

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