Functional modulation of cardiac ATP-sensitive K+ channels

被引：0

作者：

Hiraoka, M

Furukawa, T

机构：

[1] Tokyo Med & Dent Univ, Med Res Inst, Dept Cardiovasc Dis, Bunkyo Ku, Tokyo 113, Japan

[2] Tokyo Med & Dent Univ, Med Res Inst, Dept Auton Physiol, Bunkyo Ku, Tokyo 113, Japan

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 1998年 / 13卷

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D O I：

暂无

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

ATP-sensitive K+ (K-ATP) channels are inhibited by intracellular ATP, but MgATP is necessary to maintain the channel activity. Numerous cofactors modulate channel function. K+ channel openers activate and sulfonylureas inhibit K-ATP channels. The structure of cardiac K-ATP channel is a complex of mainly K(IR)6.2 and SUR2a. Activation of cardiac K-ATP channels contributes to action potential shortening during ischemia and plays a role in cardioprotection.

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页码：131 / 137

页数：7

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