Copper-catalyzed synthesis of 2,3-disubstituted quinazolin-4(3H)-ones from benzyl-substituted anthranilamides

被引：8

作者：

Foroumadi, Parham ^{[1
]}

Lotfi, Vahid ^{[4
]}

Mahdavi, Mohammad ^{[5
]}

Moghimi, Setareh ^{[2
]}

Soheiliza, Mehdi ^{[4
]}

Kianmehr, Ebrahim ^{[4
]}

Firoozpour, Loghman ^{[2
]}

Asadipour, Alj ^{[1
]}

Foroumadi, Alireza ^{[2
,3
]}

机构：

[1] Kerman Univ Med Sci, Pharmaceut Res Ctr, Inst Neuropharmacol, POB 7616913555, Kerman, Iran

[2] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Drug Design & Dev Res Ctr, POB 1417614411, Tehran, Iran

[3] Kerman Univ Med Sci, Neurosci Res Ctr, Inst Neuropharmacol, POB 7616913555, Kerman, Iran

[4] Univ Tehran, Coll Sci, Sch Chem, POB 14155-6455, Tehran, Iran

[5] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, POB 1411713137, Tehran, Iran

来源：

HETEROCYCLIC COMMUNICATIONS | 2018年 / 24卷 / 05期

关键词：

anthranilamide; copper acetate; quinazolin-4(3H)-one; TBAB; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; AEROBIC OXIDATION; QUINAZOLINONES; INHIBITORS;

D O I：

10.1515/hc-2018-0051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, practical approach to the copper-catalyzed synthesis of 2,3-disubstituted quinazolin-4(3H)-one derivatives is described. The preparation involves treatment of benzyl amines with benzyl anthranilamides in the presence of Cu(OAc)(2) and tetra-n-butylammonium bromide (TBAB).

引用

页码：267 / 271

页数：5

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