The Effect of Danofloxacine on in vitro Rat Myometrium

被引：0

作者：

Akar, Yasar ^{[4
]}

Kara, Haki ^{[1
]}

Servi, Kadir ^{[2
]}

Yildiz, Hamit ^{[3
]}

机构：

[1] Firat Univ, Fac Vet Med, Elazig Sch Hlth Sci, TR-23169 Elazig, Turkey

[2] Firat Univ, Fac Vet Med, Dept Pharmacol & Toxicol, TR-23169 Elazig, Turkey

[3] Firat Univ, Fac Vet Med, Dept Obstet & Gynecol, TR-23169 Elazig, Turkey

[4] Firat Univ, Fac Vet Med, Suleyman Demirel Keban Inst Higher Educ, TR-23169 Elazig, Turkey

来源：

PAKISTAN VETERINARY JOURNAL | 2010年 / 30卷 / 04期

关键词：

Danofloxacine; Myometrium; Oxytocin; Rat; SENSITIVE K+ CHANNELS; FLUOROQUINOLONES; NORFLOXACIN; OFLOXACIN; MUSCLES; COWS;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of this study was to determine the effect of danofloxacine on in vitro rat myometrium. The myometrium (n= 60) obtained from adult female rats. After myometrium showed spontaneous contractions, the contractions were regulated by injecting 0.1mM oxytocin. Then, 5, 10, 20, 40 and 80 mu mol danofloxacine was added to isolated organ bath in 10 min intervals, and frequency, peak amplitude and peak area calculations were recorded. With oxytocin supplementation, frequency, peak amplitude and peak area calculations were determined as 6.7 +/- 1.0, 1874 +/- 107, 1749 +/- 68, respectively. With danofloxacine supplementation, frequency and peak amplitude first increased then slowed down in relation to the dose and the peak area decreased in relation to the dose (P<0.05). In conclusion, by adding danofloxacine to the media after contractions caused by an oxytocin treatment, we observed biphasic activity. The effects of danofloxacine high doses (40 and 80 mu mol) may inhibit both K+ channels and the intracellular-induced mechanism. (c) 2010 PVJ. All rights reserved

引用

页码：211 / 214

页数：4

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