PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake

被引：34

作者：

Bailey, Julia N. ^{[1
,3
]}

Goenjian, Armen K. ^{[2
,4
]}

Noble, Ernest P. ^{[2
]}

Walling, David P. ^{[4
]}

Ritchie, Terry ^{[2
]}

Goenjian, Haig A. ^{[4
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Epidemiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat, Los Angeles, CA 90095 USA

[3] VA GLAHS Epilepsy Ctr Excellence, Epilepsy Genet Genom Labs, Comprehens Epilepsy Program, Los Angeles, CA USA

[4] Collaborat Neurosci Network, Garden Grove, CA USA

来源：

PSYCHIATRY RESEARCH | 2010年 / 178卷 / 03期

关键词：

Heritability; DRD2; DAT; PTSD; B category symptoms; POSTTRAUMATIC-STRESS-DISORDER; TRAIT LINKAGE ANALYSIS; DEPRESSIVE REACTIONS; ALLELIC ASSOCIATION; RECEPTOR GENE; TRAUMA EXPOSURE; TWIN; ADOLESCENTS; SYMPTOMS; POLYMORPHISM;

D O I：

10.1016/j.psychres.2010.04.043

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The objective of this study was to assess the generality of the association of DRD2 and DAT genes and Post-Traumatic Stress Disorder (PTSD) diagnosis/symptom severity. Two hundred ethnic Armenians from 12 multigenerational families exposed to the catastrophic 1988 Spitak earthquake were studied. Common polymorphisms A1/A2 alleles of the DRD2 and '9' repeat allele of DAT gene were genotyped. Heritability, association and linkage were assessed using variance component genetic analyses. After adjusting for the covariates, the heritabilities of PTSD diagnosis and B and C category symptoms were: 0.37, 0.75 and 0.39 respectively. Category D symptoms were not heritable. Neither the DRD2 nor the DAT polymorphisms explained the variation seen in PTSD diagnosis, total PTSD symptom severity, and categories B and C symptom severities. These findings contradict prior reports of positive associations between both DRD2 and DAT, and PTSD. Published by Elsevier Ireland Ltd.

引用

页码：507 / 510

页数：4

共 31 条

[1]

Almasy L, 1997, GENET EPIDEMIOL, V14, P953, DOI 10.1002/(SICI)1098-2272(1997)14:6<953::AID-GEPI65>3.0.CO

[2]

2-K

[3] Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes [J].

Almasy, L ;

Rainwater, DL ;

Cole, S ;

Mahaney, MC ;

Vandeberg, JL ;

Hixson, JE ;

Stern, MP ;

Maccluer, JW ;

Blangero, J .

HUMAN BIOLOGY, 2005, 77 (01) :17-25

[4] Multipoint quantitative-trait linkage analysis in general pedigrees [J].

Almasy, L ;

Blangero, J .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1198-1211

[5]

AMOS CI, 1994, AM J HUM GENET, V54, P535

[6]

BLANGERO J, 1996, SOLAR SEQUENTIAL OLI, V6

[7] GENETIC PREDISPOSITION IN ALCOHOLISM - ASSOCIATION OF THE D2 DOPAMINE RECEPTOR TAQI B1 RFLP WITH SEVERE ALCOHOLICS [J].

BLUM, K ;

NOBLE, EP ;

SHERIDAN, PJ ;

MONTGOMERY, A ;

RITCHIE, T ;

OZKARAGOZ, T ;

FITCH, RJ ;

WOOD, R ;

FINLEY, O ;

SADLACK, F .

ALCOHOL, 1993, 10 (01) :59-67

[8] Population stratification and spurious allelic association [J].

Cardon, LR ;

Palmer, LJ .

LANCET, 2003, 361 (9357) :598-604

[9] Dopamine D-2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication [J].

Comings, DE ;

Muhleman, D ;

Gysin, R .

BIOLOGICAL PSYCHIATRY, 1996, 40 (05) :368-372

[10]

Duggirala R, 1997, GENET EPIDEMIOL, V14, P987, DOI 10.1002/(SICI)1098-2272(1997)14:6<987::AID-GEPI71>3.0.CO

← 1 2 3 4 →