Four Closely Related HIV-1 CRF01_AE/CRF07_BC Recombinant Forms Identified in East China

被引：2

作者：

Li, Fan ^{[1
]}

Li, Yuxueyun ^{[1
]}

Feng, Yi ^{[1
]}

Hu, Jing ^{[1
]}

Ruan, Yuhua ^{[1
]}

Xing, Hui ^{[1
]}

Shao, Yiming ^{[1
,2
,3
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China

[2] Peking Univ, Ctr Infect Dis, Beijing, Peoples R China

[3] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 07期

基金：

中国国家自然科学基金;

关键词：

HIV-1; recombinant form; NFLG;

D O I：

10.1089/aid.2017.0049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Five near full-length genomes of novel second-generation HIV-1 recombinant virus (JS150021, JS150029, JS150129, JS150132, and AH150183) were identified from five HIV-positive people in Jiangsu and Anhui province, east China. Phylogenic analyses showed that these five sequences are all composed of two well-established circulating recombinant forms (CRFs) CRF07_BC and CRF01_AE, grouped into four new discovered recombinant forms, which show several very similar but not identical recombinant breakpoints. The four recombinant forms are also identified to be a sort of family or related viruses, seems to be the results of different recombination events. The emergence of a serious new closely related CRF07_BC/CRF01_AE recombinant strain indicates the increasing complexity of sexual transmission of the HIV-1 epidemic in China.

引用

页码：740 / 744

页数：5

共 7 条

[1] Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC [J].