The filling of powders into two-piece hard capsules

被引：24

作者：

Jones, BE

机构：

[1] Shionogi Qualicaps SA, Madrid 28100, Spain

[2] Cardiff Univ, Welsh Sch Pharm, Cardiff CF1 3FX, S Glam, Wales

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2001年 / 227卷 / 1-2期

关键词：

hard capsules; powder; filling properties; powder plug formation; instrumented machines; machine simulators; excipient properties; formulation optimisation;

D O I：

10.1016/S0378-5173(01)00781-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The factors that influence the filling of powders into hard capsules are reviewed. Powder properties that affect machine performance and influence plug formation are highlighted. The use of instrumented machines and machine simulators in formulation development are described. The properties of excipients that are required for uniform filling are identified. The use of optimisation techniques to produce rational formulations is discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：5 / 26

页数：22

共 117 条

[1]

AUGSBURGER LL, 1982, PHARM TECH, V6, P117

[2]

AUGSBURGER LL, 1982, PHARM TECH, V6, P114

[3]

Augsburger LL, 1988, STP PHARM, V4, P116

[4]

AUGSBURGER LL, 1982, PHARM TECHNOL, V6, P111