HYPOGLYCEMIC EFFECT OF CASSIA NEMOPHILA PODS EXTRACT IN STZ-INDUCED DIABETIC MICE

被引：0

作者：

Rehman, Gauhar ^{[1
]}

Hamayun, Muhammad ^{[2
]}

Iqbal, Amjad ^{[4
]}

Zaman, Khair ^{[3
]}

Arshad, Saba ^{[1
]}

Hussain, Anwar ^{[2
]}

Shah, Mohib ^{[2
]}

Gul, Sahib ^{[5
]}

Kang, Sang-Mo ^{[6
]}

Lee, In-Jung ^{[6
]}

机构：

[1] Abdul Wali Khan Univ, Dept Zool, Mardan, Pakistan

[2] Abdul Wali Khan Univ, Dept Bot, Mardan, Pakistan

[3] Abdul Wali Khan Univ, Dept Chem, Mardan, Pakistan

[4] Abdul Wali Khan Univ, Dept Agr, Mardan, Pakistan

[5] Abdul Wali Khan Univ, Dept Biochem, Mardan, Pakistan

[6] Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl BioSci, Div Plant Biosci, Daegu, South Korea

来源：

FRESENIUS ENVIRONMENTAL BULLETIN | 2018年 / 27卷 / 12A期

关键词：

Diabetes mellitus; Cassia nemophila; streptozotocin; total cholesterol; antidiabetic activity; ANTIOXIDANT ACTIVITY; LIPID-PEROXIDATION; OXIDATIVE STRESS; MEDICINAL-PLANTS; LEAVES EXTRACT; PRODUCTS; ALLOXAN; KIDNEY; SERUM; L;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Diabetes mellitus is one of the common hormonal disorders that might be controlled through herbal medicine, which is cheap, effective and safe. In the present study an attempt has been made to investigate the anti-diabetic activity of ethanolic extracts of Cassia nemophila (EECNP) in streptozotocin-induced diabetic mice. Initially, diabetes has been induced by administering a single dose (55 mg/kg body weight) of Streptozotocin and after the induction of diabetes, a dose of EECNP has been given to those mice. Laterly, blood sugar levels (BGL) at fasting and body weight of the diabetic mice have been monitored at regular intervals. Treatment of diabetic mice with EECNP has significantly decreased the BGL compared to untreated diabetic mice. Also, the diabetic mice administered with EECNP have gained normal weight on the 14th day of treatment as compared to non-treated diabetic mice. Besides, the EECNP have high antioxidant activity that have significantly affected the total cholesterol, LDL, HDL, triglycerides, MDA and nitrous oxide in the blood of diabetic mice. From the study, it is concluded that Cassia nemophila has effectively prevented the Streptozotocin-induced diabetes in the treated mice.

引用

页码：9329 / 9335

页数：7

共 39 条

[31] Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques [J].