Mitochondrial gene therapy: The tortuous path from bench to bedside

被引：11

作者：

Adhya, Samit ^{[1
]}

Mahato, Biraj ^{[1
]}

Jash, Sukanta ^{[1
]}

Koley, Sandip ^{[1
]}

Dhar, Gunjan ^{[1
]}

Chowdhury, Tapas ^{[1
]}

机构：

[1] Indian Inst Chem Biol, Genet Engn Lab, Kolkata 700032, W Bengal, India

来源：

MITOCHONDRION | 2011年 / 11卷 / 06期

关键词：

Mitochondria; Dysfunction; Gene therapy; OPTIMIZED ALLOTOPIC EXPRESSION; TRANSFER-RNA; MUTANT MITOCHONDRIA; MTDNA HETEROPLASMY; YEAST MITOCHONDRIA; MEDIATED DELIVERY; DNA REPLICATION; MESSENGER-RNA; IMPORT; MUTATIONS;

D O I：

10.1016/j.mito.2011.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The association of mitochondrial dysfunction with a variety of human diseases and disabilities has been documented. Mitochondrial gene therapy (MGT) seeks to correct the genetic defect in mitochondria! DNA. For successful MGT, an appreciation of the nature of the dysfunction and of the complexities of mitochondrial disease is necessary. This review summarizes the current status of various MGT protocols described in the literature. Although there are many technical difficulties to be overcome, there are indications that some of them will find clinical applications in the near future. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：839 / 844

页数：6

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