9.4 MHz A-line rate optical coherence tomography at 1300nm using a wavelength-swept laser based on stretched-pulse active mode-locking

被引:45
作者
Kim, Tae Shik [1 ,2 ]
Joo, JongYoon [1 ,2 ]
Shin, Inho [1 ,2 ]
Shin, Paul [1 ,2 ]
Kang, Woo Jae [1 ,2 ]
Vakoc, Benjamin J. [3 ,4 ]
Oh, Wang-Yuhl [1 ,2 ]
机构
[1] Korea Adv Inst Sci & Technol, Dept Mech Engn, Daejeon, South Korea
[2] Korea Adv Inst Sci & Technol, KI Hlth Sci & Technol, Daejeon, South Korea
[3] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA 02115 USA
基金
美国国家卫生研究院; 新加坡国家研究基金会;
关键词
AXIAL SCANS; 1310; NM; OCT; DISPERSION; ANGIOGRAPHY; MICROSCOPY; PERFORMANCE; DESIGN; RETINA; NOISE;
D O I
10.1038/s41598-020-66322-0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In optical coherence tomography (OCT), high-speed systems based at 1300nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system at 1300nm. A wavelength-swept laser based on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240nm to 1340nm, and the OCT system using this light source provides a sensitivity of 98dB and a single-sided 6-dB roll-off depth of 2.5mm. We present new capabilities of the 9.4MHz SPML-OCT system in three microscopy applications. First, we demonstrate high quality OCTA imaging at a rate of 1.3 volumes/s. Second, by utilizing its inherent phase stable characteristics, we present wide dynamic range en face Doppler OCT imaging with multiple time intervals ranging from 0.25ms to 2.0ms at a rate of 0.53 volumes/s. Third, we demonstrate video-rate 4D microscopic imaging of a beating Xenopus embryo heart at a rate of 30 volumes/s. This high-speed and high-performance OCT system centered at 1300nm suggests that it can be one of the most promising high-speed OCT platforms enabling a wide range of new scientific research, industrial, and clinical applications at speeds of 10MHz.
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页数:9
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