Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids

被引：20

作者：

Claus, Johanna ^{[1
,2
]}

Eickner, Thomas ^{[3
]}

Grabow, Niels ^{[2
,3
]}

Kragl, Udo ^{[1
,2
]}

Oschatz, Stefan ^{[3
]}

机构：

[1] Univ Rostock, Dept Chem Ind & Appl Chem, Albert Einstein Str 3A, D-18059 Rostock, Germany

[2] Univ Rostock, Dept Life Light & Matter, Albert Einstein Str 25, D-18059 Rostock, Germany

[3] Rostock Univ, Inst Biomed Engn, Med Ctr, Friedrich Barnewitz Str 4, D-18119 Rostock, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2020年 / 20卷 / 09期

关键词：

drug delivery; hydrogel; ion exchange controlled release; polymerized ionic liquids; sterilization; GAMMA-IRRADIATION; DELIVERY SYSTEM; HYALURONIC-ACID; IN-VITRO; HYDROGELS; KINETICS; PEPTIDE;

D O I：

10.1002/mabi.202000152

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3-sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly-[2-(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion-controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.

引用

页数：9

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