Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids

被引：20

作者：

Claus, Johanna ^{[1
,2
]}

Eickner, Thomas ^{[3
]}

Grabow, Niels ^{[2
,3
]}

Kragl, Udo ^{[1
,2
]}

Oschatz, Stefan ^{[3
]}

机构：

[1] Univ Rostock, Dept Chem Ind & Appl Chem, Albert Einstein Str 3A, D-18059 Rostock, Germany

[2] Univ Rostock, Dept Life Light & Matter, Albert Einstein Str 25, D-18059 Rostock, Germany

[3] Rostock Univ, Inst Biomed Engn, Med Ctr, Friedrich Barnewitz Str 4, D-18119 Rostock, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2020年 / 20卷 / 09期

关键词：

drug delivery; hydrogel; ion exchange controlled release; polymerized ionic liquids; sterilization; GAMMA-IRRADIATION; DELIVERY SYSTEM; HYALURONIC-ACID; IN-VITRO; HYDROGELS; KINETICS; PEPTIDE;

D O I：

10.1002/mabi.202000152

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3-sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly-[2-(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion-controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.

引用

页数：9

共 29 条

[1]

Abu-Thabit NY., 2018, Historical development of drug delivery systems: From conventional macroscale to controlled, targeted, and responsive nanoscale systems

[2] Effect of Gamma Irradiation on Hyaluronic Acid and Dipalmitoylphosphatidylcholine (DPPC) Interaction [J].

Ahmad, Ainee Fatimah ;

Mohd, Hur Munawar Kabir ;

bin Ayob, Muhammad Taqiyuddin Mawardi ;

Rosli, Nur Ratasha Alia Md ;

Mohamed, Faizal ;

Radiman, Shahidan ;

Rahman, Irman Abdul .

2014 UKM FST POSTGRADUATE COLLOQUIUM: PROCEEDINGS OF THE UNIVERSITI KEBANGSAAN MALAYSIA, FACULTY OF SCIENCE AND TECHNOLOGY 2014 POSTGRADUATE COLLOQUIUM, 2014, 1614 :69-73

[3] Hydrogel: Preparation, characterization, and applications: A review [J].

Ahmed, Enas M. .

JOURNAL OF ADVANCED RESEARCH, 2015, 6 (02) :105-121

[4] Usage of different vessel models in a flow-through cell: in vitro study of a novel coated balloon catheter [J].

Bandomir, Jenny ;

Kaule, Sebastian ;

Schmitz, Klaus-Peter ;

Sternberg, Katrin ;

Petersen, Svea ;

Kragl, Udo .

RSC ADVANCES, 2015, 5 (15) :11604-11610

[5] Swelling characteristics and biocompatibility of ionic liquid based hydrogels for biomedical applications [J].

Claus, Johanna ;

Brietzke, Andreas ;

Lehnert, Celina ;

Oschatz, Stefan ;

Grabow, Niels ;

Kragl, Udo .

PLOS ONE, 2020, 15 (04)

[6] Ionic liquids in biotechnology and beyond [J].

Claus, Johanna ;

Sommer, Fridolin O. ;

Kragl, Udo .

SOLID STATE IONICS, 2018, 314 :119-128

[7] A stimuli-responsive hydrogel for doxorubicin delivery [J].

Dadsetan, Mahrokh ;

Liu, Zen ;

Pumberger, Matthias ;

Giraldo, Catalina Vallejo ;

Ruesink, Terry ;

Lu, Lichun ;

Yaszemski, Michael J. .

BIOMATERIALS, 2010, 31 (31) :8051-8062

[8] Methods: A comparative analysis of radiography, microcomputed tomography, and histology for bone tissue engineering [J].

Hedberg, EL ;

Kroese-Deutman, HC ;

Shih, CK ;

Lemoine, JJ ;

Liebschner, MAK ;

Miller, MJ ;

Yasko, AW ;

Crowther, RS ;

Carney, DH ;

Mikos, AG ;

Jansen, JA .

TISSUE ENGINEERING, 2005, 11 (9-10) :1356-1367

[9] Effect of varied release kinetics of the osteogenic thrombin peptide TP508 from biodegradable, polymeric scaffolds on bone formation in vivo [J].

Hedberg, EL ;

Kroese-Deutman, HC ;

Shih, CK ;

Crowther, RS ;

Carney, DH ;

Mikos, AG ;

Jansen, JA .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2005, 72A (04) :343-353

[10] Controlled release of an osteogenic peptide from injectable biodegradable polymeric composites [J].

Hedberg, EL ;

Tang, A ;

Crowther, RS ;

Carney, DH ;

Mikos, AG .

JOURNAL OF CONTROLLED RELEASE, 2002, 84 (03) :137-150

← 1 2 3 →