Multi-modal Brain MRI in Subjects with PD and iRBD

被引：23

作者：

Mangia, Silvia ^{[1
]}

Svatkova, Alena ^{[2
,3
]}

Mascali, Daniele ^{[4
]}

Nissi, Mikko J. ^{[5
]}

Burton, Philip C. ^{[1
]}

Bednarik, Petr ^{[1
,3
]}

Auerbach, Edward J. ^{[1
]}

Giove, Federico ^{[4
,6
]}

Eberly, Lynn E. ^{[7
]}

Howell, Michael J. ^{[8
]}

Nestrasil, Igor ^{[2
]}

Tuite, Paul J. ^{[8
]}

Michaeli, Shalom ^{[1
]}

机构：

[1] Univ Minnesota, Dept Radiol, CMRR, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

[3] Masaryk Univ, Cent European Inst Technol CEITEC, Brno, Czech Republic

[4] Ctr Fermi Museo Storico, Fis & Ctr Stud Ric, Ric Enrico Fermi, MARBILab, Rome, Italy

[5] Univ Eastern Finhand, Dept Appl Phys, Kuopio, Finland

[6] IRCCS, Fdn Santa Lucia, Rome, Italy

[7] Univ Minnesota, Div Biostat, Minneapolis, MN USA

[8] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA

来源：

FRONTIERS IN NEUROSCIENCE | 2017年 / 11卷

基金：

美国国家卫生研究院; 芬兰科学院;

关键词：

rotating frame MRI; Parkinson's disease; iRBD; functional connectivity; DTI; MONTREAL COGNITIVE ASSESSMENT; ROTATING-FRAME RELAXATION; SLEEP BEHAVIOR DISORDER; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; REM-SLEEP; WHITE-MATTER; FUNCTIONAL CONNECTIVITY; MAGNETIZATION-TRANSFER; SCREENING TOOL;

D O I：

10.3389/fnins.2017.00709

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it is possible to track the neurodegeneration of individuals who may progress to PD. Here we aimed at piloting the characterization of brain tissue properties in mid-brain subcortical regions of 10 healthy subjects, 8 iRBD, and 9 early-diagnosed PD. We used a battery of magnetic resonance imaging (MRI) contrasts at 3T, including adiabatic and non-adiabatic rotating frame techniques developed by our group, along with diffusion tensor imaging (DTI) and resting-state fMRI. Adiabatic T1(rho) and T2(rho), and non-adiabatic RAFF4 (Relaxation Along a Fictitious Field in the rotating frame of rank 4) were found to have lower coefficient of variations and higher sensitivity to detect group differences as compared to DTI parameters such as fractional anisotropy and mean diffusivity. Significantly longer T1(rho) were observed in the amygdala of PD subjects vs. controls, along with a trend of lower functional connectivity as measured by regional homogeneity, thereby supporting the notion that amygdalar dysfunction occurs in PD. Significant abnormalities in reward networks occurred in iRBD subjects, who manifested lower network strength of the accumbens. In agreement with previous studies, significantly longer T1(rho) occurred in the substantia nigra compacta of PD vs. controls, indicative of neuronal degeneration, while regional homogeneity was lower in the substantia nigra reticulata. Finally, other trend-level findings were observed, i.e., lower RAFF4 and T2(rho) in the midbrain of iRBD subjects vs. controls, possibly indicating changes in non-motor features as opposed to motor function in the iRBD group. We conclude that rotating frame relaxation methods along with functional connectivity measures are valuable to characterize iRBD and PD subjects, and with proper validation in larger cohorts may provide pathological signatures of iRBD and PD.

引用

页数：12

共 89 条

[1] An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging [J].