Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer

被引：44

作者：

Xu, Peng ^{[1
,2
]}

Yao, Jia ^{[1
]}

Li, Zhen ^{[3
]}

Wang, Meng ^{[2
]}

Zhou, Linghui ^{[1
,2
]}

Zhong, Guansheng ^{[1
]}

Zheng, Yi ^{[1
,2
]}

Li, Na ^{[1
,2
]}

Zhai, Zhen ^{[1
,2
]}

Yang, Si ^{[1
,2
]}

Wu, Ying ^{[1
,2
]}

Zhang, Dai ^{[2
]}

Dai, Zhijun ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Breast Surg, Hangzhou 310003, Peoples R China

[2] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Oncol, Xian 710004, Peoples R China

[3] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Student Affairs, Xian 710004, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2020年 / 15卷

基金：

中国国家自然科学基金;

关键词：

sonodynamic therapy; co-delivery; combination chemotherapy; nanomaterials; SONODYNAMIC THERAPY; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; DAMAGE; COMBINATION; TOXICITY;

D O I：

10.2147/IJN.S243037

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Introduction: Sonodynamic Therapy (SDT) has good targeting and non-invasive advantages in solid cancers, but its antitumor effect is not sufficient to replace traditional treatments. Some studies that combined SDT with chemotherapy or nanoparticles have managed to enhance its efficiency and overcome the side effects of chemotherapy. Materials and Methods: In this study, we synthesized and characterized mesoporous silica nanoparticles (MSN-DOX-Ce6) loaded with doxorubicin (DOX) and sonosensitizer, chlorin e6 (Ce6). Then, we conducted in vitro and in vivo experiments to explore the antitumor effect of MSN-DOX-Ce6 under ultrasound (US) treatment. Results: The characterization tests showed that the nanoparticles are uniformly sized spheres with mesoporous structure, resulting in a high drug-loading efficiency. In the in vitro experiments, MSN-DOX-Ce6 could effectively inhibit cell proliferation under US but not more than other treatment groups. However, the in vivo studies showed that MSN-DOX-Ce6+US has better antitumor effect than DOX+Ce6+US or DOX alone on xenograft tumor-bearing mice. Conclusion: In summary, MSNs showed a great potential for DOX and Ce6 delivery. We concluded that under US, MSN-DOX-Ce6 nanocomposites increase the antitumor effect of DOX and SDT and thereby are a potential treatment for solid tumors.

引用

页码：2659 / 2668

页数：10

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