Stress Reactivity and Stress-Resilience in the Pathogenesis of Depressive Disorders: Involvement of Epigenetic Mechanisms

被引：2

作者：

Grigoryan, G. A. ^{[1
]}

Gulyaeva, N. V. ^{[1
]}

机构：

[1] RAS, Inst Higher Nervous Act & Neurophysiol, Moscow 117901, Russia

来源：

ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2015年 / 65卷 / 01期

关键词：

gene; histone; acetylation; methylation; depression; chronic stress of social defeat; forced swimming test; hippocampus; BDNF; GENE-ENVIRONMENT INTERACTIONS; CRH TRANSCRIPTIONAL RESPONSES; MOUSE NUCLEUS-ACCUMBENS; GYRUS GRANULE NEURONS; HISTONE ACETYLATION; GLUCOCORTICOID-RECEPTOR; DNA METHYLATION; DENTATE GYRUS; MATERNAL-DEPRIVATION; CHROMATIN REGULATION;

D O I：

10.7868/S0044467715010037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The data of epigenetic studies of stress reactivity and resilience in the pathogenesis of depression in experimental animals and humans subjected to stress at different periods of life are analyzed. Specific chromatin modifications, first of all histone acetylation and methylation, are controlling expression of definite genes in distinct brain structures. Epigenetic modulation of particular genes related to development of pro-depressive or antidepressive stress response are discussed (5HT transporter and receptors, corticotropin releasing hormone, glucocorticoid and their receptors, BDNF and other neurotrophic factors).

引用

页码：19 / 32

页数：14

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