Catalytic enantioselective aldol-type reaction of β-ketosters with Acetals

被引：54
|
作者：
Umebayashi, Natsuko [1 ,3 ]
Hamashima, Yoshitaka [1 ]
Hashizume, Daisuke [2 ]
Sodeoka, Mikiko [1 ,3 ]
机构：
[1] RIKEN, Synthet Organ Chem Lab, Wako, Saitama 3510198, Japan
[2] RIKEN, Mol Characterizat Team, Wako, Saitama 3510198, Japan
[3] Saitama Univ, Grad Sch Sci & Engn, Sakura Ku, Saitama 3388570, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 22期
关键词：
beta-ketoester; acetal; aldol reaction; palladium; platinum;
D O I：
10.1002/anie.200705344
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Two activations, one catalyst: By using cationic Pd and Pt complexes, a catalytic enantioselective aldol-type reaction of β-ketoesters with acetals has been developed (see scheme). The formation of metal enolates occurs under acidic conditions to allow the use of acetals as electrophiles to give the desired aldol products in high diastereoseletivity and enantioselectivity. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4196 / 4199
页数：4
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