Effect of cytokines on neuronal excitability

被引：184

作者：

Schaefers, Maria ^{[1
]}

Sorkin, Linda ^{[2
]}

机构：

[1] Univ Duisburg Essen, Dept Neurol, D-45147 Essen, Germany

[2] Univ Calif San Diego, Anesthesiol Res Lab, La Jolla, CA 92093 USA

来源：

NEUROSCIENCE LETTERS | 2008年 / 437卷 / 03期

关键词：

cytokines; neuronal excitability; ion channels; pain; tumor-necrosis factor-alpha; interleukin-1; beta;

D O I：

10.1016/j.neulet.2008.03.052

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Numerous studies have shown that proinflammatory cytokines induce or facilitate pain and hyperalgesia in the presence of inflammation, injury to the nervous system or cancer. Besides acting as inflammatory mediators, increasing evidence indicates that cytokines may also specifically interact with receptor and ion channels regulating neuronal excitability, synaptic plasticity and injury under both physiological and pathological conditions. Here we summarize findings on two prototypical proinflammatory cytokines, tumor-necrosis factor-alpha and interleukin-1 beta, and their effects on neuronal excitability and ion channels with special regards to pain and hyperalgesia. (C) 2008 Elsevier Ireland Ltd. All Fights reserved.

引用

页码：188 / 193

页数：6

共 73 条

[1] Control of synaptic strength by glial TNFα [J].

Beattie, EC ;

Stellwagen, D ;

Morishita, W ;

Bresnahan, JC ;

Ha, BK ;

Von Zastrow, M ;

Beattie, MS ;

Malenka, RC .

SCIENCE, 2002, 295 (5563) :2282-2285

[2] INTERLEUKIN-1-BETA INHIBITS SYNAPTIC STRENGTH AND LONG-TERM POTENTIATION IN THE RAT CA1 HIPPOCAMPUS [J].

BELLINGER, FP ;

MADAMBA, S ;

SIGGINS, GR .

BRAIN RESEARCH, 1993, 628 (1-2) :227-234

[3] Existence of Bayesian estimates for the polychotomous quantal response models [J].

Chen, MH ;

Shao, QM .

ANNALS OF THE INSTITUTE OF STATISTICAL MATHEMATICS, 1999, 51 (04) :637-656

[4] Interleukin-1β suppresses epithelial sodium channel β-subunit expression and ENaGdependent fluid absorption in human middle ear epithelial cells [J].

Choi, Jae Young ;

Choi, Yoon-Seok ;

Kim, Su Jin ;

Son, Eun Jin ;

Choi, Hyun Seung ;

Yoon, Joo-Heon .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 567 (1-2) :19-25

[5] Role of TNF-alpha in sensitization of nociceptive dorsal horn neurons induced by application of nucleus pulposus to L5 dorsal root ganglion in rats [J].

Cuellar, JM ;

Montesano, P ;

Carstens, E .

PAIN, 2004, 110 (03) :578-587

[6] Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro [J].

Cunningham, AJ ;

Murray, CA ;

ONeill, LAJ ;

Lynch, MA ;

OConnor, JJ .

NEUROSCIENCE LETTERS, 1996, 203 (01) :17-20

[7] Reduction of excitation by interleukin-1 beta in rat neocortical slices visualized using infrared-darkfield videomicroscopy [J].

DArcangelo, G ;

Dodt, HU ;

Zieglgansberger, W .

NEUROREPORT, 1997, 8 (08) :2079-2083

[8] From cellular receptors to transduction-transcription pathways for cytokines: at which level should the inhibition be targeted in inflammation? [J].

Dayer, JM ;

Molnarfi, N ;

Burger, D .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2005, 5 :S83-S96

[9] Tumor necrosis factor α increases cytosolic calcium responses to AMPA and KCl in primary cultures of rat hippocampal neurons [J].

De, A ;

Krueger, JM ;

Simasko, SM .

BRAIN RESEARCH, 2003, 981 (1-2) :133-142

[10] Interleukin 1β modulates rat subfornical organ neurons as a result of activation of a non-selective cationic conductance [J].

Desson, SE ;

Ferguson, AV .

JOURNAL OF PHYSIOLOGY-LONDON, 2003, 550 (01) :113-122

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