Effect of in vitro Glycation on Hemoglobin Variants and Influence of Hemoglobin Traits on Glycated Hemoglobin Dosage by Chromatographic Method

被引：0
|
作者：
Nagy, Eniko Nemes [1 ]
Tilinca, Mariana [1 ]
Ormenisan, Alina [2 ]
Hancu, Violeta [3 ]
Comaneanu, Raluca Monica [3 ]
Fazakas, Zita [1 ]
Fodor, Marta Andrea [1 ,4 ]
Higgins, Trefor
机构：
[1] Univ Med & Pharm Targu Mures, Fac Med, 38 Gh Marinescu Str, Targu Mures 540139, Romania
[2] Univ Med & Pharm Targu Mures, Fac Med Dent, 38 Gh Marinescu Str, Targu Mures 540139, Romania
[3] Titu Maiorescu Univ Bucharest, Fac Med Dent, 67A Gh Petrascu, Bucharest 031593, Romania
[4] Dynalifedx Lab, Dept Clin Biochem, Edmonton, AB, Canada
来源：
REVISTA DE CHIMIE | 2016年 / 67卷 / 11期
关键词：
diabetes mellitus; glycated hemoglobin; hemoglobinopathies; in vitro glycosylation; HPLC;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The accuracy of glycated hemoglobin (HbA1c) dosage is essential for the proper monitoring of treatment in diabetic patients. Cromatographic methods are widely used for HbA1c dosage. Hemoglobin variants can influence the HbA1c test results. Purpose of the research was in vitro glycation of blood samples, especially those containing hemoglobin traits, to reveal peaks that could correspond to glycated hemoglobin variants. Another purpose was evaluation of persistent HbF incidence and hemoglobinopathies in the population of Transylvania. The practical approach is increase the accurary of HbA1c measurement by chromatographic methods identifying these interferences.
引用
收藏
页码：2170 / 2175
页数：6
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