Mutual regulation between the spindle checkpoint and APC/C

被引：82

作者：

Kim, Soonjoung ^{[1
]}

Yu, Hongtao ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dept Pharmacol, Dallas, TX 75390 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2011年 / 22卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Mitosis; Chromosome segregation; Cell cycle; Ubiquitination; ANAPHASE-PROMOTING COMPLEX; KINETOCHORE-MICROTUBULE INTERFACE; SISTER-CHROMATID COHESION; PROTEIN PHOSPHATASE 2A; ASSEMBLY CHECKPOINT; MITOTIC CHECKPOINT; CONFORMATIONAL DIMERIZATION; CHROMOSOME-CONGRESSION; PROCESSIVITY FACTOR; CRYSTAL-STRUCTURE;

D O I：

10.1016/j.semcdb.2011.03.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accurate chromosome segregation during mitosis is critical for maintaining genomic stability. The spindle checkpoint is a cellular surveillance system that ensures the fidelity of chromosome segregation. In response to sister chromatids not properly captured by spindle microtubules, the spindle checkpoint interferes with the functions of Cdc20, the mitotic activator of the anaphase-promoting complex or cyclosome (APC/C), thereby blocking APC/C-mediated degradation of securin and cyclin B to delay anaphase onset. This review summarizes the recent progress on the mechanisms by which checkpoint proteins inhibit APC/C, the conformational and enzymatic activation of checkpoint proteins, and the emerging roles of APC/C-dependent ubiquitination in checkpoint inactivation. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：551 / 558

页数：8

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