Physical regulation of stem cells differentiation into teno-lineage: current strategies and future direction

被引：32

作者：

Chen, Jia Lin ^{[1
,2
]}

Zhang, Wei ^{[1
,2
]}

Liu, Ze Yu ^{[1
,2
]}

Heng, Boon Chin ^{[3
]}

Ouyang, Hong Wei ^{[1
,2
,4
]}

Dai, Xue Song ^{[5
]}

机构：

[1] Zhejiang Univ, Sch Med, Ctr Stem Cell & Tissue Engn, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Prov Key Lab Tissue Engn & Regenerat Med, Hangzhou, Zhejiang, Peoples R China

[3] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland

[4] Zhejiang Univ, Sch Med, Dept Sports Med, Hangzhou 310003, Zhejiang, Peoples R China

[5] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped, Hangzhou 310009, Zhejiang, Peoples R China

来源：

CELL AND TISSUE RESEARCH | 2015年 / 360卷 / 02期

基金：

国家高技术研究发展计划(863计划);

关键词：

Mechanical stimulation; Extracellular matrix topography; Tendon differentiation; Tendon development; Stepwise differentiation; PROMOTED OSTEOGENIC DIFFERENTIATION; MESENCHYMAL PROGENITOR CELLS; SUBMICRON FIBROUS SCAFFOLDS; MESSENGER-RNA EXPRESSION; FOCAL ADHESION KINASE; MARROW STROMAL CELLS; COLLAGEN TYPE-I; TENOGENIC DIFFERENTIATION; BONE-MARROW; TENDON REPAIR;

D O I：

10.1007/s00441-014-2077-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tendon injuries are commonly encountered in the clinic, disrupting the patient's normal work/life routine and damaging the career life of athletes. Currently, there is still no effective treatment for tendon injury. Tendon tissue engineering appears to be a promising route for tendon repair and regeneration. However, current strategies utilized in research are still far away from clinical applications due to unsuccessful cellular differentiation to tendon/tenocytes. In this review, we focus on the current physical strategies (mechanical stimulation and extracellular matrix topography) and evaluate their roles in precise and stepwise tendon differentiation. A systematic comprehension of normal tendon development process by structure, gene profile and physical microenvironment analysis is likely suggestive for stepwise tenocyte differentiation.

引用

页码：195 / 207

页数：13

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