Physical regulation of stem cells differentiation into teno-lineage: current strategies and future direction

被引：33

作者：

Chen, Jia Lin ^{[1
,2
]}

Zhang, Wei ^{[1
,2
]}

Liu, Ze Yu ^{[1
,2
]}

Heng, Boon Chin ^{[3
]}

Ouyang, Hong Wei ^{[1
,2
,4
]}

Dai, Xue Song ^{[5
]}

机构：

[1] Zhejiang Univ, Sch Med, Ctr Stem Cell & Tissue Engn, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Prov Key Lab Tissue Engn & Regenerat Med, Hangzhou, Zhejiang, Peoples R China

[3] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland

[4] Zhejiang Univ, Sch Med, Dept Sports Med, Hangzhou 310003, Zhejiang, Peoples R China

[5] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped, Hangzhou 310009, Zhejiang, Peoples R China

来源：

CELL AND TISSUE RESEARCH | 2015年 / 360卷 / 02期

基金：

国家高技术研究发展计划(863计划);

关键词：

Mechanical stimulation; Extracellular matrix topography; Tendon differentiation; Tendon development; Stepwise differentiation; PROMOTED OSTEOGENIC DIFFERENTIATION; MESENCHYMAL PROGENITOR CELLS; SUBMICRON FIBROUS SCAFFOLDS; MESSENGER-RNA EXPRESSION; FOCAL ADHESION KINASE; MARROW STROMAL CELLS; COLLAGEN TYPE-I; TENOGENIC DIFFERENTIATION; BONE-MARROW; TENDON REPAIR;

D O I：

10.1007/s00441-014-2077-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tendon injuries are commonly encountered in the clinic, disrupting the patient's normal work/life routine and damaging the career life of athletes. Currently, there is still no effective treatment for tendon injury. Tendon tissue engineering appears to be a promising route for tendon repair and regeneration. However, current strategies utilized in research are still far away from clinical applications due to unsuccessful cellular differentiation to tendon/tenocytes. In this review, we focus on the current physical strategies (mechanical stimulation and extracellular matrix topography) and evaluate their roles in precise and stepwise tendon differentiation. A systematic comprehension of normal tendon development process by structure, gene profile and physical microenvironment analysis is likely suggestive for stepwise tenocyte differentiation.

引用

页码：195 / 207

页数：13

共 96 条

[11] Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche [J].

Bi, Yanming ;

Ehirchiou, Driss ;

Kilts, Tina M. ;

Inkson, Colette A. ;

Embree, Mildred C. ;

Sonoyama, Wataru ;

Li, Li ;

Leet, Arabella I. ;

Seo, Byoung-Moo ;

Zhang, Li ;

Shi, Songtao ;

Young, Marian F. .

NATURE MEDICINE, 2007, 13 (10) :1219-1227

[12] A somitic compartment of tendon progenitors [J].

Brent, AE ;

Schweitzer, R ;

Tabin, CJ .

CELL, 2003, 113 (02) :235-248

[13] Functional efficacy of tendon kepair processes [J].

Butler, DL ;

Juncosa, N ;

Dressler, MR .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2004, 6 :303-329

[14]

Caliari SR, 2014, ADV HEALTHC IN PRESS

[15] Electrospun fibre diameter, not alignment, affects mesenchymal stem cell differentiation into the tendon/ligament lineage [J].

Cardwell, Robyn D. ;

Dahlgren, Linda A. ;

Goldstein, Aaron S. .

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2014, 8 (12) :937-945

[16] Effect of growth and differentiation factor 6 on the tenogenic differentiation of bone marrow-derived mesenchymal stem cells [J].

Chai Wei ;

Ni Ming ;

Rui Yun-feng ;

Zhang Kai-yi ;

Zhang Qiang ;

Xu Liang-liang ;

Chan Kai-ming ;

Li Gang ;

Wang Yan .

CHINESE MEDICAL JOURNAL, 2013, 126 (08) :1509-1516

[17] Are Bone Marrow Mesenchymal Stem Cells-Induced Tenogenic Progenitor Cells Identical to Tendon Progenitor Cells? [J].

Chen, Hui ;

Rui, Yun Feng ;

Wang, Chen .

STEM CELLS AND DEVELOPMENT, 2012, 21 (06) :844-845

[18] Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles [J].

Chen, Jia Lin ;

Yin, Zi ;

Shen, Wei Liang ;

Chen, Xiao ;

Heng, Boon Chin ;

Zou, Xiao Hui ;

Ouyang, Hong Wei .

BIOMATERIALS, 2010, 31 (36) :9438-9451

[19] Autologous Platelet-rich Clot Releasate Stimulates Proliferation and Inhibits Differentiation of Adult Rat Tendon Stem Cells Towards Nontenocyte Lineages [J].

Chen, L. ;

Dong, S-W ;

Tao, X. ;

Liu, J-P ;

Tang, K-L ;

Xu, J-Z .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2012, 40 (04) :1399-1409

[20] Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytes [J].

Chen, Xiao ;

Yin, Zi ;

Chen, Jia-lin ;

Shen, Wei-liang ;

Liu, Huan-huan ;

Tang, Qiao-mei ;

Fang, Zhi ;

Lu, Lin-rong ;

Ji, Junfeng ;

Ouyang, Hong-wei .

SCIENTIFIC REPORTS, 2012, 2

← 1 2 3 4 5 6 7 8 9 10 →