Physical regulation of stem cells differentiation into teno-lineage: current strategies and future direction

被引：33
作者：
Chen, Jia Lin [1 ,2 ]
Zhang, Wei [1 ,2 ]
Liu, Ze Yu [1 ,2 ]
Heng, Boon Chin [3 ]
Ouyang, Hong Wei [1 ,2 ,4 ]
Dai, Xue Song [5 ]
机构：
[1] Zhejiang Univ, Sch Med, Ctr Stem Cell & Tissue Engn, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Prov Key Lab Tissue Engn & Regenerat Med, Hangzhou, Zhejiang, Peoples R China
[3] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland
[4] Zhejiang Univ, Sch Med, Dept Sports Med, Hangzhou 310003, Zhejiang, Peoples R China
[5] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped, Hangzhou 310009, Zhejiang, Peoples R China
来源：
CELL AND TISSUE RESEARCH | 2015年 / 360卷 / 02期
基金：
国家高技术研究发展计划(863计划);
关键词：
Mechanical stimulation; Extracellular matrix topography; Tendon differentiation; Tendon development; Stepwise differentiation; PROMOTED OSTEOGENIC DIFFERENTIATION; MESENCHYMAL PROGENITOR CELLS; SUBMICRON FIBROUS SCAFFOLDS; MESSENGER-RNA EXPRESSION; FOCAL ADHESION KINASE; MARROW STROMAL CELLS; COLLAGEN TYPE-I; TENOGENIC DIFFERENTIATION; BONE-MARROW; TENDON REPAIR;
D O I：
10.1007/s00441-014-2077-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tendon injuries are commonly encountered in the clinic, disrupting the patient's normal work/life routine and damaging the career life of athletes. Currently, there is still no effective treatment for tendon injury. Tendon tissue engineering appears to be a promising route for tendon repair and regeneration. However, current strategies utilized in research are still far away from clinical applications due to unsuccessful cellular differentiation to tendon/tenocytes. In this review, we focus on the current physical strategies (mechanical stimulation and extracellular matrix topography) and evaluate their roles in precise and stepwise tendon differentiation. A systematic comprehension of normal tendon development process by structure, gene profile and physical microenvironment analysis is likely suggestive for stepwise tenocyte differentiation.
引用
收藏
页码：195 / 207
页数：13
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