Physical regulation of stem cells differentiation into teno-lineage: current strategies and future direction

被引：32
作者：
Chen, Jia Lin [1 ,2 ]
Zhang, Wei [1 ,2 ]
Liu, Ze Yu [1 ,2 ]
Heng, Boon Chin [3 ]
Ouyang, Hong Wei [1 ,2 ,4 ]
Dai, Xue Song [5 ]
机构：
[1] Zhejiang Univ, Sch Med, Ctr Stem Cell & Tissue Engn, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Prov Key Lab Tissue Engn & Regenerat Med, Hangzhou, Zhejiang, Peoples R China
[3] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland
[4] Zhejiang Univ, Sch Med, Dept Sports Med, Hangzhou 310003, Zhejiang, Peoples R China
[5] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped, Hangzhou 310009, Zhejiang, Peoples R China
来源：
CELL AND TISSUE RESEARCH | 2015年 / 360卷 / 02期
基金：
国家高技术研究发展计划(863计划);
关键词：
Mechanical stimulation; Extracellular matrix topography; Tendon differentiation; Tendon development; Stepwise differentiation; PROMOTED OSTEOGENIC DIFFERENTIATION; MESENCHYMAL PROGENITOR CELLS; SUBMICRON FIBROUS SCAFFOLDS; MESSENGER-RNA EXPRESSION; FOCAL ADHESION KINASE; MARROW STROMAL CELLS; COLLAGEN TYPE-I; TENOGENIC DIFFERENTIATION; BONE-MARROW; TENDON REPAIR;
D O I：
10.1007/s00441-014-2077-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tendon injuries are commonly encountered in the clinic, disrupting the patient's normal work/life routine and damaging the career life of athletes. Currently, there is still no effective treatment for tendon injury. Tendon tissue engineering appears to be a promising route for tendon repair and regeneration. However, current strategies utilized in research are still far away from clinical applications due to unsuccessful cellular differentiation to tendon/tenocytes. In this review, we focus on the current physical strategies (mechanical stimulation and extracellular matrix topography) and evaluate their roles in precise and stepwise tendon differentiation. A systematic comprehension of normal tendon development process by structure, gene profile and physical microenvironment analysis is likely suggestive for stepwise tenocyte differentiation.
引用
收藏
页码：195 / 207
页数：13
相关论文
共 96 条
[1]   Tendon Tissue Engineering Using Cell-Seeded Umbilical Veins Cultured in a Mechanical Stimulator [J].
Abousleiman, Rita I. ;
Reyes, Yuliana ;
McFetridge, Peter ;
Sikavitsas, Vassilios .
TISSUE ENGINEERING PART A, 2009, 15 (04) :787-795
[2]   Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis [J].
Alberton, Paolo ;
Popov, Cvetan ;
Praegert, Markus ;
Kohler, Julia ;
Shukunami, Chisa ;
Schieker, Matthias ;
Docheva, Denitsa .
STEM CELLS AND DEVELOPMENT, 2012, 21 (06) :846-858
[3]   Cell differentiation by mechanical stress [J].
Altman, GH ;
Horan, RL ;
Martin, I ;
Farhadi, J ;
Stark, PRH ;
Volloch, V ;
Richmond, JC ;
Vunjak-Novakovic, G ;
Kaplan, DL .
FASEB JOURNAL, 2001, 15 (14) :270-+
[4]   Mechanical, Compositional, and Structural Properties of the Post-natal Mouse Achilles Tendon [J].
Ansorge, Heather L. ;
Adams, Sheila ;
Birk, David E. ;
Soslowsky, Louis J. .
ANNALS OF BIOMEDICAL ENGINEERING, 2011, 39 (07) :1904-1913
[5]  
Awad HA, 2000, J BIOMED MATER RES, V51, P233, DOI 10.1002/(SICI)1097-4636(200008)51:2<233::AID-JBM12>3.0.CO
[6]  
2-B
[7]   Tissue engineering for tendon repair [J].
Bagnaninchi, Pierre-Olivier ;
Yang, Ying ;
El Haj, Alicia J. ;
Maffulli, Nicola .
BRITISH JOURNAL OF SPORTS MEDICINE, 2007, 41 (08)
[8]   Derivation of engraftable skeletal myoblasts from human embryonic stem cells [J].
Barberi, Tiziano ;
Bradbury, Michelle ;
Dincer, Zehra ;
Panagiotakos, Georgia ;
Socci, Nicholas D. ;
Studer, Lorenz .
NATURE MEDICINE, 2007, 13 (05) :642-648
[9]   Indirect Co-Culture with Tendons or Tenocytes Can Program Amniotic Epithelial Cells towards Stepwise Tenogenic Differentiation [J].
Barboni, Barbara ;
Curini, Valentina ;
Russo, Valentina ;
Mauro, Annunziata ;
Di Giacinto, Oriana ;
Marchisio, Marco ;
Alfonsi, Melissa ;
Mattioli, Mauro .
PLOS ONE, 2012, 7 (02)
[10]  
Barsby T, 2014, TISSUE EN A IN PRESS
12345678910