Nutraceuticals as potential therapeutic agents for colon cancer: a review

被引：81

作者：

Kuppusamy, Palaniselvam ^{[1
]}

Yusoff, Mashitah M. ^{[1
]}

Maniam, Gaanty Pragas ^{[1
]}

Ichwan, Solachuddin Jauhari Arief ^{[2
]}

Soundharrajan, Ilavenil ^{[3
]}

Govindan, Natanamurugaraj ^{[1
]}

机构：

[1] Univ Malaysia Pahang, Fac Ind Sci & Technol, Mammalian Cell Technol Lab, Kuantan 26300, Pahang, Malaysia

[2] Int Islamic Univ Malaysia, Kulliyyah Dent, Kuantan 25200, Pahang, Malaysia

[3] Natl Inst Anim Sci, Dept Biochem, Suwon 441706, Gyeonggi, South Korea

来源：

ACTA PHARMACEUTICA SINICA B | 2014年 / 4卷 / 03期

关键词：

Colon cancer; Nutraceuticals; Therapeutics; Marine organisms; Plant derivatives; CELL-CYCLE ARREST; COLORECTAL-CANCER; METABOLIC PATHWAYS; FATTY-ACIDS; APOPTOSIS; PREVENTION; PROLIFERATION; INHIBITION; EXPRESSION; MODULATION;

D O I：

10.1016/j.apsb.2014.04.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Colon cancer is a world-wide health problem and the second -most dangerous type of cancer, affecting both men and women. The modern diet and lifestyles, with high meat consumption and excessive alcohol use, along with limited physical activity has led to an increasing mortality rate for colon cancer worldwide. As a result, there is a need to develop novel and environmentally benign drug therapies for colon cancer. Currently, nutraceuticals play an increasingly important role in the treatment of various chronic diseases such as colon cancer, diabetes and Alzheimer's disease. Nutraceuticals are derived from various natural sources such as medicinal plants, marine organisms, vegetables and fruits. Nutraceuticals have shown the potential to reduce the risk of colon cancer and slow its progression. These dietary substances target different molecular aspects of colon cancer development. Accordingly, this review briefly discusses the medicinal importance of nutraceuticals and their ability to reduce the risk of colorectal carcinogenesis. (C) 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：173 / 181

页数：9

共 84 条

[31] Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells [J].