Synthesis and Free Radical Scavenging Activity of Coumarin Derivatives Containing a 2-Methylbenzothiazoline Motif

被引：69

作者：

Khoobi, Mehdi ^{[2
]}

Emami, Saeed ^{[3
,4
]}

Dehghan, Gholamreza ^{[5
]}

Foroumadi, Alireza ^{[1
,6
]}

Ramazani, Ali ^{[2
]}

Shafiee, Abbas ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm & Pharmaceut Sci, Res Ctr, Tehran 14176, Iran

[2] Zanjan Univ, Dept Chem, Zanjan, Iran

[3] Mazandaran Univ Med Sci, Dept Med Chem, Sari, Iran

[4] Mazandaran Univ Med Sci, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran

[5] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran

[6] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran 14176, Iran

来源：

ARCHIV DER PHARMAZIE | 2011年 / 344卷 / 09期

基金：

美国国家科学基金会;

关键词：

ABTS; Antioxidants; Benzothiazoline; Coumarin; DPPH; Radical scavenging activity; ANTIOXIDANT;

D O I：

10.1002/ardp.201000271

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Coumarin and benzothiazole scaffolds can be found in a number of natural or synthetic antioxidants. In an effort to develop a novel radical scavenger and potential antioxidant, a series of coumarin derivatives containing 2-methylbenzothiazoline motif and related compounds was synthesized and evaluated for their DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS(center dot+) (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radicals scavenging activities. Among them, 7-hydroxy-3-(2-methyl-2,3-dihydrobenzo[d]-thiazol-2-yl)-2H-chromen-2-one (3e) has shown a significant free radical scavenging activity. From the structure-activity point of view, it was found that phenolic coumarin ring and benzothiazoline moiety in target compounds may contribute to the scavenging activity against free radicals.

引用

页码：588 / 594

页数：7

共 19 条

[1] Lipid peroxidation and cataracts: N-Acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes [J].