Intravesical oxybutynin therapy for patients with neurogenic detrusor overactivity: a systematic review and meta-analysis

被引:9
作者
Shen, Si-hong [1 ]
Jia, Xue [2 ]
Peng, Liao [1 ]
Zeng, Xiao [1 ]
Shen, Hong [1 ]
Luo, De-yi [1 ]
机构
[1] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, West China Sch Med, Dept Postgrad, Chengdu 610041, Sichuan, Peoples R China
关键词
Adult; Children; Intravesical; Neurogenic detrusor overactivity; Oxybutynin; CLEAN INTERMITTENT CATHETERIZATION; ADULT PATIENTS; BLADDER; CHLORIDE; CHILDREN; PHARMACOKINETICS; INSTILLATION; EFFICACY; SAFETY; DYSFUNCTION;
D O I
10.1007/s11255-022-03129-0
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose To evaluate the effectiveness and safety of intravesical oxybutynin therapy for patients with neurogenic detrusor overactivity. Methods A systematic search in PubMed, MEDLINE, EMBASE, ClinicalTrial.gov, and Cochrane Controlled Trials Register was conducted from 1990 to 2021. Nineteen studies were included for analysis, of which 392 patients including both adults and children were treated with intravesical oxybutynin. The analysis was performed by Cochrane RevMan (R) software, version 5.3. The primary outcomes were maximum bladder capacity (MBC), detrusor pressure at MBC, and bladder compliance. The secondary outcomes were episodes of urinary incontinence and side effects. Results MBC displayed an increase of 77.8 ml (95% CI 56.9 to 98.7) in kids, 110.8 ml (95% CI 58.95 to 162.7) in adults, respectively. Detrusor pressure at MBC demonstrated an improvement of - 18.8 cm H2O (95% CI - 26.2 to - 11.3) in kids, - 23.2 cm H2O (95% CI - 32.6 to - 13.8) in adults, respectively. The bladder compliance increased 5.8 ml/cm H2O (95% CI 3.4 to 8.1) among kids. The mean percentage of patients "dry or improved" after treatment accounted for 76.9% in adults and 74.6% in kids, respectively. Among all patients, 53 (13.5%) reported side effects, 80 (20.4%) discontinued this treatment, 26 (6.6%) withdrew because of side effects, and 35 (8.9%) quit due to inconvenience. Conclusion Intravesical oxybutynin treatment could be a feasible treatment for both adults and children with neurogenic detrusor overactivity, because of its good effect and less side effects.
引用
收藏
页码:737 / 747
页数:11
相关论文
共 48 条
[1]  
Åmark P, 1998, BRIT J UROL, V82, P859
[2]  
BISHARA D, 2021, J AM MED DIR ASSOC
[3]   TOPICAL OXYBUTYNIN CHLORIDE FOR RELAXATION OF DYSFUNCTIONAL BLADDERS [J].
BRENDLER, CB ;
RADEBAUGH, LC ;
MOHLER, JL .
JOURNAL OF UROLOGY, 1989, 141 (06) :1350-1352
[4]   Intravesical application of a stable oxybutynin solution improves therapeutic compliance and acceptance in children with neurogenic bladder dysfunction [J].
Buyse, G ;
Verpoorten, C ;
Vereecken, R ;
Casaer, P .
JOURNAL OF UROLOGY, 1998, 160 (03) :1084-1087
[5]   Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study [J].
Coupland, Carol A. C. ;
Hill, Trevor ;
Dening, Tom ;
Morriss, Richard ;
Moore, Michael ;
Hippisley-Cox, Julia .
JAMA INTERNAL MEDICINE, 2019, 179 (08) :1084-1093
[6]   Intravesical oxybutynin: A local anesthetic effect on bladder C afferents [J].
De Wachter, S ;
Wyndaele, JJ .
JOURNAL OF UROLOGY, 2003, 169 (05) :1892-1895
[7]   Lesson of the week - Oxybutynin and cognitive dysfunction [J].
Donnellan, CA ;
Fook, L ;
McDonald, P ;
Playfer, JR .
BRITISH MEDICAL JOURNAL, 1997, 315 (7119) :1363-1364
[8]   Efficacy of Combined Oral-Intravesical Oxybutynin Hydrochloride Treatment for Patients with Overactive Detrusors and Indwelling Urethral Catheters [J].
Ersoz, Murat ;
Yidiz, Necmettin ;
Akyuz, Mufit ;
Koseoglu, Fusun .
REHABILITATION NURSING, 2010, 35 (02) :80-U1
[9]   Side-effects of oral or intravesical oxybutynin chloride in children with spina bifida [J].
Ferrara, P ;
D'Aleo, CM ;
Tarquini, E ;
Salvatore, S ;
Salvaggio, E .
BJU INTERNATIONAL, 2001, 87 (07) :674-677
[10]   The effects of anticholinergic drugs on attention span and short-term memory skills in children [J].
Giramonti, Karla M. ;
Kogan, Barry A. ;
Halpern, Leslie F. .
NEUROUROLOGY AND URODYNAMICS, 2008, 27 (04) :315-318