Acquired protein C and protein S deficiency in HIV-infected patients

被引:55
作者
Erbe, M
Rickerts, V
Bauersachs, RM
Lindhoff-Last, E
机构
[1] Univ Hosp Frankfurt, Dept Internal Med, Div Angiol, D-60590 Frankfurt, Germany
[2] Univ Hosp Frankfurt, Dept Internal Med, Div Infect Dis, D-60590 Frankfurt, Germany
关键词
HIV; thrombosis; protein S deficiency; protein C deficiency;
D O I
10.1177/107602960300900408
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Infection with human immunodeficiency virus (HIV) may lead to hemostatic imbalances. Forty-nine consecutive patients with acute opportunistic infections were screened for thrombophilic parameters. A follow-up investigation was performed after 10+/-8 weeks in 26 patients. In acutely ill patients, the incidence of protein S deficiency was 67% (33/49) and of protein C deficiency 25% (12/49), while at the follow-up visit the incidences were 54% (14/26) and 8% (2/26), respectively. Protein S and protein C levels increased significantly from initial to follow-up visit (p < 0.05). Lupus anticoagulants were not detected and anticardiolipin IgG antibodies were present in 11.4% (5/44). Three patients presented with deep venous thrombosis on admission; in two, protein S or protein C deficiency was observed. in conclusion, an acquired protein S and protein C deficiency often develop in patients with HIV and acute illness; this may be reversible after treatment for opportunistic infections.
引用
收藏
页码:325 / 331
页数:7
相关论文
共 29 条
[1]  
ABUAF N, 1997, THROMB HAEMOSTASIS, V77, P835
[2]   INCREASED RISK OF VENOUS THROMBOSIS IN CARRIERS OF HEREDITARY PROTEIN-C DEFICIENCY DEFECT [J].
ALLAART, CF ;
POORT, SR ;
ROSENDAAL, FR ;
REITSMA, PH ;
BERTINA, RM ;
BRIET, E .
LANCET, 1993, 341 (8838) :134-138
[3]  
BISSUEL F, 1992, J ACQ IMMUN DEF SYND, V5, P484
[4]   Coagulation activation in patients with an inflammatory syndrome:: is there a link with acquired protein S deficiency? [J].
Boullanger, N ;
El Kouri, D ;
Trossaërt, M ;
Truchaud, F ;
Trewick, D ;
Planchon, B .
BLOOD COAGULATION & FIBRINOLYSIS, 1998, 9 (02) :167-171
[5]   Human immunodeficiency virus type 1-related transient neurological deficits [J].
Brew, BJ ;
Miller, J .
AMERICAN JOURNAL OF MEDICINE, 1996, 101 (03) :257-261
[6]  
CHAFA O, 1992, THROMB HAEMOSTASIS, V67, P1
[7]   Hemostatic abnormalities in inflammatory bowel disease [J].
Chiarantini, E ;
Valanzano, R ;
Liotta, AA ;
Cellai, AP ;
Fedi, S ;
Ilari, I ;
Prisco, D ;
Tonelli, F ;
Abbate, R .
THROMBOSIS RESEARCH, 1996, 82 (02) :137-146
[8]   ACQUIRED DEFICIENCIES OF PROTEIN-S - PROTEIN-S ACTIVITY DURING ORAL ANTICOAGULATION, IN LIVER-DISEASE, AND IN DISSEMINATED INTRAVASCULAR COAGULATION [J].
DANGELO, A ;
VIGANODANGELO, S ;
ESMON, CT ;
COMP, PC .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (05) :1445-1454
[9]  
Dolan G, 1989, Baillieres Clin Haematol, V2, P999, DOI 10.1016/S0950-3536(89)80055-1
[10]  
FAIR DS, 1986, BLOOD, V67, P64