Gap-induced reductions of evoked potentials in the auditory cortex: A possible objective marker for the presence of tinnitus in animals

被引:17
作者
Berger, Joel I. [1 ]
Owen, William [1 ]
Wilson, Caroline A. [1 ]
Hockley, Adam [1 ]
Coomber, Ben [1 ]
Palmer, Alan R. [1 ]
Wallace, Mark N. [1 ]
机构
[1] Univ Nottingham, Sch Med, MRC, Inst Hearing Res, Univ Pk, Nottingham NG7 2RD, England
关键词
Tinnitus; Auditory cortex; Noise exposure; Chronic recording; ACOUSTIC STARTLE REFLEX; AWAKE GUINEA-PIGS; NOISE EXPOSURE; PREPULSE INHIBITION; DETECTION DEFICITS; HEARING-LOSS; SILENT GAPS; RATS; RESPONSES; ENHANCEMENT;
D O I
10.1016/j.brainres.2017.11.026
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Animal models of tinnitus are essential for determining the underlying mechanisms and testing pharmacotherapies. However, there is doubt over the validity of current behavioural methods for detecting tinnitus. Here, we applied a stimulus paradigm widely used in a behavioural test (gap-induced inhibition of the acoustic startle reflex GPIAS) whilst recording from the auditory cortex, and showed neural response changes that mirror those found in the behavioural tests. We implanted guinea pigs (GPs) with electrocorticographic (ECoG) arrays and recorded baseline auditory cortical responses to a startling stimulus. When a gap was inserted in otherwise continuous background noise prior to the startling stimulus, there was a clear reduction in the subsequent evoked response (termed gap-induced reductions in evoked potentials; GIREP), suggestive of a neural analogue of the GPIAS test. We then unilaterally exposed guinea pigs to narrowband noise (left ear; 8-10 kHz; 1 h) at one of two different sound levels - either 105 dB SPL or 120 dB SPL - and recorded the same responses seven-to-ten weeks following the noise exposure. Significant deficits in GIREP were observed for all areas of the auditory cortex (AC) in the 120 dB-exposed GPs, but not in the 105 dB-exposed GPs. These deficits could not simply be accounted for by changes in response amplitudes. Furthermore, in the contralateral (right) caudal AC we observed a significant increase in evoked potential amplitudes across narrowband background frequencies in both 105 dB and 120 dB-exposed GPs. Taken in the context of the large body of literature that has used the behavioural test as a demonstration of the presence of tinnitus, these results are suggestive of objective neural correlates of the presence of noise-induced tinnitus and hyperacusis. (C) 2017 The Authors. Published by Elsevier B.V.
引用
收藏
页码:101 / 108
页数:8
相关论文
共 51 条
[1]   Hypersensitivity to sound - Questionnaire data, audiometry and classification [J].
Anari, M ;
Axelsson, A ;
Eliasson, A ;
Magnusson, L .
SCANDINAVIAN AUDIOLOGY, 1999, 28 (04) :219-230
[2]  
Axelsson Alf, 2000, Noise Health, V2, P47
[3]   Behavioral model of chronic tinnitus in rats [J].
Bauer, CA ;
Brozoski, TJ ;
Rojas, R ;
Boley, J ;
Wyder, M .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1999, 121 (04) :457-462
[4]   Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs [J].
Berger, Joel I. ;
Coomber, Ben ;
Wallace, Mark N. ;
Palmer, Alan R. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2017, 45 (03) :398-409
[5]   Changes in the response properties of inferior colliculus neurons relating to tinnitus [J].
Berger, Joel I. ;
Coomber, Ben ;
Wells, Tobias T. ;
Wallace, Mark N. ;
Palmer, Alan R. .
FRONTIERS IN NEUROLOGY, 2014, 5
[6]   A novel behavioural approach to detecting tinnitus in the guinea pig [J].
Berger, Joel I. ;
Coomber, Ben ;
Shackleton, Trevor M. ;
Palmer, Alan R. ;
Wallace, Mark N. .
JOURNAL OF NEUROSCIENCE METHODS, 2013, 213 (02) :188-195
[7]   The Gap Detection Test: Can It Be Used to Diagnose Tinnitus? [J].
Boyen, Kris ;
Baskent, Deniz ;
van Dijk, Pim .
EAR AND HEARING, 2015, 36 (04) :e138-e145
[8]   Does tinnitus "fill in" the silent gaps [J].
Campolo, Jennifer ;
Lobarinas, Edward ;
Salvi, Richard .
NOISE & HEALTH, 2013, 15 (67) :398-405
[9]   Neural changes accompanying tinnitus following unilateral acoustic trauma in the guinea pig [J].
Coomber, Ben ;
Berger, Joel I. ;
Kowalkowski, Victoria L. ;
Shackleton, Trevor M. ;
Palmer, Alan R. ;
Wallace, Mark N. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2014, 40 (02) :2427-2441
[10]   Assessment and amelioration of hyperacusis in tinnitus patients [J].
Dauman, R ;
Bouscau-Faure, F .
ACTA OTO-LARYNGOLOGICA, 2005, 125 (05) :503-509