The role of microRNAs in Epstein-Barr virus latency and lytic reactivation

被引：54
作者：
Forte, Eleonora
Luftig, Micah A. [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA
来源：
MICROBES AND INFECTION | 2011年 / 13卷 / 14-15期
关键词：
Epstein-Barr virus; EBV; microRNA; miRNA; B-cell lymphoma; LMP1; miR-155; miR-34; miR-146; miR-200; Lytic reactivation; ZEB; EPITHELIAL-MESENCHYMAL TRANSITION; MIR-200; FAMILY; DIFFERENTIAL EXPRESSION; MEMBRANE PROTEIN-1; REPRESSORS ZEB1; B-CELLS; MIR-155; RNAS; TARGET; LMP1;
D O I：
10.1016/j.micinf.2011.07.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Oncogenic viruses reprogram host gene expression driving proliferation, ensuring survival, and evading the immune response. The recent appreciation of microRNAs (miRNAs) as small non-coding RNAs that broadly regulate gene expression has provided new insight into this complex scheme of host control. This review highlights the role of viral and cellular miRNAs during the latent and lytic phases of the EBV life cycle. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1156 / 1167
页数：12
相关论文
共 77 条
[1]   Quantitative Studies of Epstein-Barr Virus-Encoded MicroRNAs Provide Novel Insights into Their Regulation [J].
Amoroso, Richard ;
Fitzsimmons, Leah ;
Thomas, Wendy A. ;
Kelly, Gemma L. ;
Rowe, Martin ;
Bell, Andrew I. .
JOURNAL OF VIROLOGY, 2011, 85 (02) :996-1010
[2]   Epstein-Barr virus encoded LMP1 downregulates TCL1 oncogene through miR-29b [J].
Anastasiadou, E. ;
Boccellato, F. ;
Vincenti, S. ;
Rosato, P. ;
Bozzoni, I. ;
Frati, L. ;
Faggioni, A. ;
Presutti, C. ;
Trivedi, P. .
ONCOGENE, 2010, 29 (09) :1316-1328
[3]   The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell [J].
Babcock, GJ ;
Hochberg, D ;
Thorley-Lawson, DA .
IMMUNITY, 2000, 13 (04) :497-506
[4]   EBV persistence in memory B cells in vivo [J].
Babcock, GJ ;
Decker, LL ;
Volk, M ;
Thorley-Lawson, DA .
IMMUNITY, 1998, 9 (03) :395-404
[5]   MicroRNAs: Target Recognition and Regulatory Functions [J].
Bartel, David P. .
CELL, 2009, 136 (02) :215-233
[6]   Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5 [J].
Barth, Stephanie ;
Pfuhl, Thorsten ;
Mamiani, Alfredo ;
Ehses, Claudia ;
Roemer, Klaus ;
Kremmer, Elisabeth ;
Jaeker, Christoph ;
Hoeck, Julia ;
Meister, Gunter ;
Graesser, Friedrich A. .
NUCLEIC ACIDS RESEARCH, 2008, 36 (02) :666-675
[7]   A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells [J].
Burk, Ulrike ;
Schubert, Joerg ;
Wellner, Ulrich ;
Schmalhofer, Otto ;
Vincan, Elizabeth ;
Spaderna, Simone ;
Brabletz, Thomas .
EMBO REPORTS, 2008, 9 (06) :582-589
[8]   Epstein-Barr virus MicroRNAs are evolutionarily conserved and differentially expressed [J].
Cai, Xuezhong ;
Schafer, Alexandra ;
Lu, Shihua ;
Bilello, John P. ;
Desrosiers, Ronald C. ;
Edwards, Rachel ;
Raab-Traub, Nancy ;
Cullen, Bryan R. .
PLOS PATHOGENS, 2006, 2 (03) :236-247
[9]   Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways [J].
Cameron, Jennifer E. ;
Yin, Qinyan ;
Fewell, Claire ;
Lacey, Michelle ;
McBride, Jane ;
Wang, Xia ;
Lin, Zhen ;
Schaefer, Brian C. ;
Flemington, Erik K. .
JOURNAL OF VIROLOGY, 2008, 82 (04) :1946-1958
[10]   Epstein-Barr virus growth/latency III program alters cellular microRNA expression [J].
Cameron, Jennifer E. ;
Fewell, Claire ;
Yin, Qinyan ;
McBride, Jane ;
Wang, Xia ;
Lin, Zhen ;
Flemington, Erik K. .
VIROLOGY, 2008, 382 (02) :257-266
12345678