Animal models and intestinal drug transport

被引：10
作者：
Glaeser, Hartmut [1 ]
Fromm, Martin F. [1 ]
机构：
[1] Univ Erlangen Nurnberg, Inst Expt & Clin Pharmacol & Toxicol, D-91054 Erlangen, Germany
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2008年 / 4卷 / 04期
关键词：
ABC transporter; absorption; animal models; bioavailability; drug transporter; elimination; intestine; uptake transporter;
D O I：
10.1517/17425255.4.4.347
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Intestinal drug metabolism and transport are now well recognized determinants of drug disposition in humans. During the last decade, various animal models lacking drug transporters have been generated in order to investigate the role of transporters for drug absorption, distribution and elimination. Objective: In this review the use of the animal models for the investigation of intestinal drug transport will be discussed. Methods: Publications describing the use of knockout animals (e.g., P-glycoprotein, Bcrp, and Oct1) regarding intestinal drug transport and animals characterized by mutations in transporters genes (e.g., Mrp2) were mainly considered for this review. Results/conclusion: Knockout mouse models for ABC transporters are highly valuable tools to investigate the role of intestinal efflux transporters for the bioavailability of various compounds.
引用
收藏
页码：347 / 361
页数：15
相关论文
共 98 条
[1]   Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen [J].
Adachi, Y ;
Suzuki, H ;
Schinkel, AH ;
Sugiyama, Y .
MOLECULAR PHARMACOLOGY, 2005, 67 (03) :923-928
[2]   Enteric excretion of baicalein, a flavone of scutellariae radix, via glucuronidation in rat: Involvement of multidrug resistance-associated protein 2 [J].
Akao, T ;
Sakashita, Y ;
Hanada, M ;
Goto, H ;
Shimada, Y ;
Terasawa, K .
PHARMACEUTICAL RESEARCH, 2004, 21 (11) :2120-2126
[3]  
Allen JD, 2003, CANCER RES, V63, P1339
[4]   Organic anion transporter family: Current knowledge [J].
Anzai, Naohiko ;
Kanai, Yoshikatsu ;
Endou, Hitoshi .
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 100 (05) :411-426
[5]  
Brangi M, 1999, CANCER RES, V59, P5938
[6]  
Buchler M, 1996, J BIOL CHEM, V271, P15091
[7]  
CHEN AY, 1991, CANCER RES, V51, P6039
[8]  
Chu XY, 1997, CANCER RES, V57, P1934
[9]   Characterization of mice lacking the multidrug resistance protein Mrp2 (Abcc2) [J].
Chu, XY ;
Strauss, JR ;
Mariano, MA ;
Li, J ;
Newton, DJ ;
Cai, XX ;
Wang, RW ;
Yabut, J ;
Hartley, DP ;
Evans, DC ;
Evers, R .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 317 (02) :579-589
[10]  
Chu XY, 2001, J PHARMACOL EXP THER, V299, P575
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