Ovarian mucinous tumor of gastric and intestinal type associated with Peutz-Jeghers syndrome;: in situ hybridization study of apomucin gene transcripts

Occurrence of mucinous tumors is favored by Peutz-Jeghers syndrome (PJS). A case of bilateral oval-lan mucinous tumor associated with ovarian mature teratoma occuring in a 22-year-old woman with PJS was reported. Tumor cells included 5 cell types: tall columnar mucinous pale cells with neutral mucins; goblet cells with acidic nonsulfated mucins; non mucinous columnar cells; mucinous cuboidal cells lining small glands; endocrine cells. Expression of the MUC2, MUC3, MUC5AC and MUC6 genes was demonstrated by in situ hybridization according to cell type. Some atypia and numerous mitotic figures were observed in basal glands. Diagnosis was ovarian borderline mucinous tumor with gastric and intestinal phenotype associated with PJS.