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- [1] Population pharmacokinetics of PQR309, a dual PI3K/mTOR inhibitor in adult patients with advanced solid tumorsJOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)Machacek, Matthias论文数: 0 引用数: 0 h-index: 0Renaud, Lionel论文数: 0 引用数: 0 h-index: 0Dimitrijevic, Sasa论文数: 0 引用数: 0 h-index: 0Schmitz, Debora论文数: 0 引用数: 0 h-index: 0Ivanova, Elena论文数: 0 引用数: 0 h-index: 0Jorga, Karin论文数: 0 引用数: 0 h-index: 0
- [2] First-in human, phase 1, dose-escalation pharmacokinetic and pharmacodynamic study of the oral dual PI3K and mTORC1/2 inhibitor PQR309 in patients with advanced solid tumors (SAKK 67/13)EUROPEAN JOURNAL OF CANCER, 2018, 96 : 6 - 16Wicki, Andreas论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandBrown, Nicholas论文数: 0 引用数: 0 h-index: 0机构: Univ Coll London Hosp NHS Trust, Gynecol Oncol Team, 235 Euston Rd, London NW1 2BU, England Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandXyrafas, Alexandros论文数: 0 引用数: 0 h-index: 0机构: SAKK Coordinating Ctr, Effingerstr 33, CH-3008 Bern, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandBize, Vincent论文数: 0 引用数: 0 h-index: 0机构: SAKK Coordinating Ctr, Effingerstr 33, CH-3008 Bern, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandHawle, Hanne论文数: 0 引用数: 0 h-index: 0机构: SAKK Coordinating Ctr, Effingerstr 33, CH-3008 Bern, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandBerardi, Simona论文数: 0 引用数: 0 h-index: 0机构: SAKK Coordinating Ctr, Effingerstr 33, CH-3008 Bern, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandCmiljanovic, Natasa论文数: 0 引用数: 0 h-index: 0机构: Piqur Therapeut AG, Hochbergstr 60C, CH-4057 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandCmiljanovic, Vladimir论文数: 0 引用数: 0 h-index: 0机构: Piqur Therapeut AG, Hochbergstr 60C, CH-4057 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandStumm, Michael论文数: 0 引用数: 0 h-index: 0机构: Piqur Therapeut AG, Hochbergstr 60C, CH-4057 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandDimitrijevic, Sasa论文数: 0 引用数: 0 h-index: 0机构: Piqur Therapeut AG, Hochbergstr 60C, CH-4057 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandHerrmann, Richard论文数: 0 引用数: 0 h-index: 0机构: Piqur Therapeut AG, Hochbergstr 60C, CH-4057 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandPretre, Vincent论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Basel, Dept Biomed, Petersgraben 4, CH-4031 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandRitschard, Reto论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Basel, Dept Biomed, Petersgraben 4, CH-4031 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandTzankov, Alexandar论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Basel, Dept Pathol, Schonbeinstr 40, CH-4056 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandHess, Viviane论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandChilds, Alexa论文数: 0 引用数: 0 h-index: 0机构: Univ Coll London Hosp NHS Trust, Gynecol Oncol Team, 235 Euston Rd, London NW1 2BU, England Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandHierro, Cinta论文数: 0 引用数: 0 h-index: 0机构: Univ Autonoma Barcelona, Vall dHebron Inst Oncol, Passeig Vall dHebron 119-129, Barcelona 08035, Spain Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandRodon, Jordi论文数: 0 引用数: 0 h-index: 0机构: Univ Autonoma Barcelona, Vall dHebron Inst Oncol, Passeig Vall dHebron 119-129, Barcelona 08035, Spain Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandHess, Dagmar论文数: 0 引用数: 0 h-index: 0机构: Cantonal Hosp St Gallen, Dept Hematol & Oncol, Rorschacherstr 95, CH-9007 St Gallen, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandJoerger, Markus论文数: 0 引用数: 0 h-index: 0机构: Cantonal Hosp St Gallen, Dept Hematol & Oncol, Rorschacherstr 95, CH-9007 St Gallen, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, Switzerlandvon Moos, Roger论文数: 0 引用数: 0 h-index: 0机构: Cantonal Hosp Graubunden, Dept Hematol & Oncol, Loestr 170, CH-7000 Chur, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandSessa, Cristiana论文数: 0 引用数: 0 h-index: 0机构: Osped San Giovanni Bellinzona, Ist Oncol Svizzera Italiana, CH-6500 Bellinzona, Switzerland Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, SwitzerlandKristeleit, Rebecca论文数: 0 引用数: 0 h-index: 0机构: Univ Coll London Hosp NHS Trust, Gynecol Oncol Team, 235 Euston Rd, London NW1 2BU, England Univ Hosp Basel, Div Oncol, Dept Biomed, Petersgraben 4, CH-4031 Basel, Switzerland
- [3] A phase 1 study of the PI3K/mTOR inhibitor PQR309 evaluating safety, pharmacokinetics (PK) and pharmacodynamics (PD) in patients (pts) with advanced solid tumors.JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)Adjei, Alex A.论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USADy, Grace K.论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USAZhao, Yujie论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USAMa, Wen Wee论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USAOpyrchal, Mateusz论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USABakhribah, Hatoon论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USAJacob, Sandra M.论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USAO'Hara, Corrie论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USADozier, Askia论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USACmiljanovic, Natasa论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USATodaro, Barbara论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USABrady, William E.论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USASchmitz, Debora论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USADimitrijevic, Sasa论文数: 0 引用数: 0 h-index: 0机构: Roswell Pk Canc Inst, Buffalo, NY 14263 USA
- [4] A Dose-Escalation (DE) Study with Expansion Evaluating Safety, Pharmacokinetics and Efficacy of the Novel, Balanced PI3K/mTOR Inhibitor PQR309 in Patients with Relapsed or Refractory LymphomaBLOOD, 2016, 128 (22)Collins, Graham P.论文数: 0 引用数: 0 h-index: 0机构: Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, England Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandPopat, Rakesh论文数: 0 引用数: 0 h-index: 0机构: NHS Fdn Trust, Univ Coll London Hosp, Haematol, London, England Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandStathis, Anastasios论文数: 0 引用数: 0 h-index: 0机构: Oncol Inst Southern Switzerland, Clin Res Unit, Bellinzona, Switzerland Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandKrasniqi, Fatime论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Basel, Switzerland Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandEyre, Toby A.论文数: 0 引用数: 0 h-index: 0机构: Churchill Hosp Canc Ctr, Dept Haematol, Oxford, England Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandNg, Chin Hin论文数: 0 引用数: 0 h-index: 0机构: NHS Fdn Trust, Univ Coll London Hosp, NIHR UCLH Clin Res Facil, London, England Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandEl-Sharkawi, Dima论文数: 0 引用数: 0 h-index: 0机构: NHS Fdn Trust, Univ Coll London Hosp, NIHR UCLH Clin Res Facil, London, England Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandSchmidt, Christian论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Grosshadern LMU, Dept Med III, Munich, Germany Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, England论文数: 引用数: h-index:机构:Ivanova, Elena论文数: 0 引用数: 0 h-index: 0机构: PIQUR Therapeut AG, Basel, Switzerland Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandSchmitz, Debora论文数: 0 引用数: 0 h-index: 0机构: PIQUR Therapeut AG, Basel, Switzerland Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandDimitrijevic, Sasa论文数: 0 引用数: 0 h-index: 0机构: PIQUR Therapeut AG, Basel, Switzerland Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, EnglandDreyling, Martin H.论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Grosshadern LMU, Dept Med III, Munich, Germany Oxford NIHR Biomed Res Ctr, Churchill Hosp, Oxford, England
- [5] Final results of the pharmacodynamic (PD) data of PQR309-001 a first-in-human trial of a combined PI3K/mTOR inhibitor in advanced solid tumorsCANCER RESEARCH, 2016, 76Wicki, Andreas论文数: 0 引用数: 0 h-index: 0Pretre, Vincent论文数: 0 引用数: 0 h-index: 0Ritschard, Reto论文数: 0 引用数: 0 h-index: 0Brown, Nicholas论文数: 0 引用数: 0 h-index: 0Bize, Vincent论文数: 0 引用数: 0 h-index: 0Fabbro, Thomas论文数: 0 引用数: 0 h-index: 0Cmiljanovic, Natasa论文数: 0 引用数: 0 h-index: 0Dimitrijevic, Sasa论文数: 0 引用数: 0 h-index: 0Schmitz, Deborah论文数: 0 引用数: 0 h-index: 0Stumm, Michael论文数: 0 引用数: 0 h-index: 0Kristeleit, Rebecca论文数: 0 引用数: 0 h-index: 0
- [6] Phase I Dose-Escalation Study of Taselisib, an Oral PI3K Inhibitor, in Patients with Advanced Solid TumorsCANCER DISCOVERY, 2017, 7 (07) : 704 - 715Juric, Dejan论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAKrop, Ian论文数: 0 引用数: 0 h-index: 0机构: Dana Farber Canc Inst, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USARamanathan, Ramesh K.论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin, Scottsdale, AZ USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAWilson, Timothy R.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAWare, Joseph A.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USABohorquez, Sandra M. Sanabria论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USASavage, Heidi M.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USASampath, Deepak论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USASalphati, Laurent论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USALin, Ray S.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAJin, Huan论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAParmar, Hema论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAHsu, Jerry Y.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAVon Hoff, Daniel D.论文数: 0 引用数: 0 h-index: 0机构: Virginia G Piper Canc Ctr Honor Hlth, Scottsdale, AZ USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USABaselga, Jose论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave,Box 20, New York, NY 10065 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA
- [7] A first-in-human phase I study of intravenous PI3K inhibitor BAY 80-6946 in patients with advanced solid tumors: Results of dose-escalation phase.JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)Patnaik, A.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USAAppleman, L. J.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USAMountz, J. M.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USARamanathan, R. K.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USABeeram, M.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USATolcher, A. W.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USAPapadopoulos, K. P.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USALotze, M. T.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USAPetro, D. P.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USALaymon, C.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USAPaige, L.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USARajagopalan, P.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USAJeffers, M.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USARoth, D.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USADubowy, R. L.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut START Ctr C, San Antonio, TX USA
- [8] A first-in-human dose-escalation study of the oral proteasome inhibitor oprozomib in patients with advanced solid tumorsINVESTIGATIONAL NEW DRUGS, 2016, 34 (02) : 216 - 224Infante, Jeffrey R.论文数: 0 引用数: 0 h-index: 0机构: Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USAMendelson, David S.论文数: 0 引用数: 0 h-index: 0机构: Pinnacle Oncol Hematol, Scottsdale, AZ USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USABurris, Howard A., III论文数: 0 引用数: 0 h-index: 0机构: Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USABendell, Johanna C.论文数: 0 引用数: 0 h-index: 0机构: Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USATolcher, Anthony W.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut, San Antonio, TX USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USAGordon, Michael S.论文数: 0 引用数: 0 h-index: 0机构: Pinnacle Oncol Hematol, Scottsdale, AZ USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USAGillenwater, Heidi H.论文数: 0 引用数: 0 h-index: 0机构: Onyx Pharmaceut Inc, San Francisco, CA USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USAArastu-Kapur, Shirin论文数: 0 引用数: 0 h-index: 0机构: Onyx Pharmaceut Inc, San Francisco, CA USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USAWong, Hansen L.论文数: 0 引用数: 0 h-index: 0机构: Onyx Pharmaceut Inc, San Francisco, CA USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USAPapadopoulos, Kyriakos P.论文数: 0 引用数: 0 h-index: 0机构: South Texas Accelerated Res Therapeut, San Antonio, TX USA Sarah Cannon Res Inst, Tennessee Oncol, 250 25th Ave North, Nashville, TN 37203 USA
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