5,6-dihydroindolizines as convenient precursors of indolizidine 167B and analogues

被引：10

作者：

Guazzelli, G ^{[1
]}

Lazzaroni, R ^{[1
]}

Settambolo, R ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim & Chim Ind, CNR, ICCOM, I-56126 Pisa, Italy

来源：

SYNTHESIS-STUTTGART | 2005年 / 18期

关键词：

(-)-indolizidine 16713; 5,6-dihydroindolizines; synthesis; 4-(pyrrol-l-yl)butanal; enantioselective hydrogenation;

D O I：

10.1055/s-2005-918407

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 5-carboxyethyl-5,6-dihydroindolizine, the title alkaloid was obtained in 25% overall yield via differently C5-substituted 5,6-dihydroindolizines and final exhaustive hydrogenation. An alternative strategy for the synthesis of optically active indolizidine 167B and analogues still based on 5,6-dihydroindolizine intermediates is given.

引用

页码：3119 / 3123

页数：5

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