Gold Nanoparticles-Decorated Silicon Nanowires as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Cells Destruction

被引:139
作者
Su, Yuanyuan [1 ,2 ,3 ,4 ]
Wei, Xinpan [3 ,4 ]
Peng, Fei [3 ,4 ]
Zhong, Yiling [3 ,4 ]
Lu, Yimei [3 ,4 ]
Su, Shao [3 ,4 ]
Xu, Tingting [1 ,2 ,3 ,4 ]
Lee, Shuit-Tong [1 ,2 ]
He, Yao [3 ,4 ]
机构
[1] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong, Hong Kong, Peoples R China
[2] City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong, Hong Kong, Peoples R China
[3] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China
[4] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China
关键词
Silicon nanowires; hyperthermia agent; cancer photothermal therapy; near-infrared; nanobioapplications; SURFACE-PLASMON RESONANCE; PHOTOTHERMAL THERAPY; SILVER NANOPARTICLES; CARBON NANOTUBES; QUANTUM DOTS; IN-VITRO; NANOSPHERES; ABSORPTION; ABLATION; NANORODS;
D O I
10.1021/nl204203t
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Near-infrared (NIR) hyperthermia agents are of current interest because they hold great promise as highly efficacious tools for cancer photothermal therapy. Although various agents have been reported, a practical NIR hyperthermia agent is yet unavailable. Here, we present the first demonstration that silicon nanomaterials-based NIR hyperthermia agent, that is, gold nanoparticles-decorated silicon nanowires (AuNPs@SiNWs), is capable of high-efficiency destruction of cancer cells. AuNPs@SiNWs are found to possess strong optical absorbance in the NIR spectral window, producing sufficient heat under NIB. irradiation. AuNPs@SiNWs are explored as novel NIR hyperthermia agents for photothermal ablation of tumor cells. In particular, three different cancer cells treated with AuNPs@SiNWs were completely destructed within 3 min of NIR irradiation, demonstrating the exciting potential of AuNPs@SiNWs for NIR hyperthermia agents.
引用
收藏
页码:1845 / 1850
页数:6
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