Highly methoxylated pectin improves insulin, resistance and other cardiometabolic risk factors in Zucker fatty rats

被引：54
作者：
Sanchez, D. [1 ]
Muguerza, B. [2 ]
Moulay, L. [2 ]
Hernandez, R. [3 ]
Miguel, M. [1 ]
Aleixandre, A. [1 ]
机构：
[1] Univ Complutense, Dept Farmacol, Fac Med, E-28040 Madrid, Spain
[2] Natraceut Grp, Valencia 46930, Spain
[3] Hosp Cent Def CDEAS, Madrid 28027, Spain
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2008年 / 56卷 / 10期
关键词：
apple pectin; beta-glucan; fiber; metabolic syndrome; Zucker rats;
D O I：
10.1021/jf703598j
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
In this study, we evaluated the effect of a highly methoxylated apple pectin (HMAP) on cardiometabolic risk factors in Zucker fatty rats. P-Glucan, a fiber known for its hypocholesterolemic properties, also was used. The rats fed both fiber-enriched diets exhibited a reduction, in body weight and in total cholesterol and triglycerides when compared to the Zucker fatty rats fed the standard diet. The effect on the lipid profile was more remarkable in the HMAP group. A decrease in blood glucose was only noticed in this group. Moreover, a decrease in plasma insulin, HOMA-IR, and HOMA-beta was noticed in the fiber groups, and in particular in the HMAP group, these variables being similar to the lean rats. Blood pressure and endothelial function were similar in all the Zucker fatty rats. These results warrant evaluation in humans to determine if HMAP could be used as a functional ingredient to reduce lipid profile, insulin resistance, and other cardiometabolic risk factors.
引用
收藏
页码：3574 / 3581
页数：8
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