Highly methoxylated pectin improves insulin, resistance and other cardiometabolic risk factors in Zucker fatty rats

被引：54

作者：

Sanchez, D. ^{[1
]}

Muguerza, B. ^{[2
]}

Moulay, L. ^{[2
]}

Hernandez, R. ^{[3
]}

Miguel, M. ^{[1
]}

Aleixandre, A. ^{[1
]}

机构：

[1] Univ Complutense, Dept Farmacol, Fac Med, E-28040 Madrid, Spain

[2] Natraceut Grp, Valencia 46930, Spain

[3] Hosp Cent Def CDEAS, Madrid 28027, Spain

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2008年 / 56卷 / 10期

关键词：

apple pectin; beta-glucan; fiber; metabolic syndrome; Zucker rats;

D O I：

10.1021/jf703598j

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

In this study, we evaluated the effect of a highly methoxylated apple pectin (HMAP) on cardiometabolic risk factors in Zucker fatty rats. P-Glucan, a fiber known for its hypocholesterolemic properties, also was used. The rats fed both fiber-enriched diets exhibited a reduction, in body weight and in total cholesterol and triglycerides when compared to the Zucker fatty rats fed the standard diet. The effect on the lipid profile was more remarkable in the HMAP group. A decrease in blood glucose was only noticed in this group. Moreover, a decrease in plasma insulin, HOMA-IR, and HOMA-beta was noticed in the fiber groups, and in particular in the HMAP group, these variables being similar to the lean rats. Blood pressure and endothelial function were similar in all the Zucker fatty rats. These results warrant evaluation in humans to determine if HMAP could be used as a functional ingredient to reduce lipid profile, insulin resistance, and other cardiometabolic risk factors.

引用

页码：3574 / 3581

页数：8

共 74 条

[1] Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old [J].

Adams, Kenneth F. ;

Schatzkin, Arthur ;

Harris, Tamara B. ;

Kipnis, Victor ;

Mouw, Traci ;

Ballard-Barbash, Rachel ;

Hollenbeck, Albert ;

Leitzmann, Michael F. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (08) :763-778

[2] Effect of soluble fiber intake in lipid and glucose leves in healthy subjects: a randomized clinical trial [J].

Aller, R ;

de Luis, DA ;

Izaola, O ;

La Calle, F ;

del Olmo, L ;

Fernandez, L ;

Arranz, T ;

Hernandez, JMG .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2004, 65 (01) :7-11

[3]

Anderson JW, 2000, AM J CLIN NUTR, V71, P1433

[4]

Anderson JW, 2000, AM J CLIN NUTR, V71, P472

[5] Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats [J].

Aprikian, O ;

Duclos, V ;

Guyot, S ;

Besson, C ;

Manach, C ;

Bernalier, A ;

Morand, C ;

Rémésy, C ;

Demigné, C .

JOURNAL OF NUTRITION, 2003, 133 (06) :1860-1865

[6] Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese Zucker rats [J].

Aprikian, O ;

Busserolles, J ;

Manach, C ;

Mazur, A ;

Morand, C ;

Davicco, MJ ;

Besson, C ;

Rayssiguier, Y ;

Rémésy, C ;

Demigné, C .

JOURNAL OF NUTRITION, 2002, 132 (07) :1969-1976

[7] The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats [J].

Artiss, JD ;

Brogan, K ;

Brucal, M ;

Moghaddam, M ;

Jen, KLC .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2006, 55 (02) :195-202

[8] Anomalous lipoproteins in obese Zucker rats [J].

Blay, M ;

Peinado-Onsurbe, J ;

Julve, J ;

Rodríguez, V ;

Fernández-López, JA ;

Remesar, X ;

Alemany, M .

DIABETES OBESITY & METABOLISM, 2001, 3 (04) :259-270

[9] Dietary fibre, glycaemic response, and diabetes [J].

Brennan, CS .

MOLECULAR NUTRITION & FOOD RESEARCH, 2005, 49 (06) :560-570

[10]

Brown L, 1999, AM J CLIN NUTR, V69, P30

← 1 2 3 4 5 6 7 8 →