Making the invisible visible: searching for human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in Brazilian patients with viral hepatitis B and C

被引：18

作者：

Caterino-de-Araujo, Adele ^{[1
]}

Alves, Fabiana Aparecida ^{[1
]}

Campos, Karoline Rodrigues ^{[1
]}

Lemos, Marcilio Figueiredo ^{[2
]}

Moreira, Regina Celia ^{[2
]}

机构：

[1] Secretaria Estado Saude Sao Paulo, Coordenadoria Controle Doencas, Inst Adolfo Lutz, Ctr Imunol,Lab Pesquisa HTLV, Sao Paulo, SP, Brazil

[2] Secretaria Estado Saude Sao Paulo, Coordenadoria Controle Doencas, Inst Adolfo Lutz,Lab Hepatites, Ctr Virol,Nucleo Doencas Transmissao Sanguinea &, Sao Paulo, SP, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2018年 / 113卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

HBV; HCV; HIV; HTLV-1/-2; co-infection; HUMAN-IMMUNODEFICIENCY-VIRUS; RISK-FACTORS; COINFECTION; INFECTION; IMPACT; HIV; POPULATION; PREVALENCE; SALVADOR; OUTCOMES;

D O I：

10.1590/0074-02760170307

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

With this study, the authors hope to alert clinicians regarding the presence of human T-cell lymphotropic virus type 1 and 2 (HTLV-1/-2) infections in patients with viral hepatitis B and C in Brazil. HTLV-1/-2 were detected in 1.3% of hepatitis B virus (HBV)- and 5.3% of hepatitis C virus (HCV)-infected blood samples sent for laboratory viral load measurements. A partial association of human immunodeficiency virus (HIV)-1 and HTLV-1/-2 infection was detected in patients with HCV (HIV+, 27.3%), whereas this association was almost 100% in HBV-infected patients (HIV+, all except one). The high prevalence of HTLV-1/-2 infection among patients with hepatitis C was of concern, as HTLV-1/-2 could change the natural course of subsequent liver disease. The authors suggest including HTLV-1/-2 serology in the battery of tests used when following patients with viral hepatitis in Brazil, regardless of the HIV status.

引用

页码：130 / 134

页数：5

共 29 条

[1] Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs [J].