An Efficient One-Pot Three-Component Reaction for Synthesis of Spirooxindole Derivatives in Water Media under Catalyst-Free Condition

被引：35
|
作者：
Zhao, Liqin [1 ]
Zhou, Bo [1 ]
Li, Yiqun [1 ]
机构：
[1] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
来源：
HETEROATOM CHEMISTRY | 2011年 / 22卷 / 05期
基金：
中国国家自然科学基金;
关键词：
SOLVENT-FREE CONDITION; MULTICOMPONENT REACTIONS; AQUEOUS-MEDIUM; MALONONITRILE; INHIBITORS; ISATINS; FACILE;
D O I：
10.1002/hc.20723
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient, clean, and environmentally benign synthesis of spirooxindole derivatives by one-pot three-component reaction of isatins, malononitrile, and carbonyl compound in the absence of catalysis in water was described. A variety of spirooxindole derivatives were obtained with excellent yields within short reaction time. This novel protocol has the advantages of convenient operation, low cost, and environmental benign. (C) 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:673-677, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20723
引用
收藏
页码：673 / 677
页数：5
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