Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience

被引：36

作者：

Aquilante, Christina L. ^{[1
,2
]}

Kao, David P. ^{[1
]}

Trinkley, Katy E. ^{[1
,3
]}

Lin, Chen-Tan ^{[1
,4
]}

Crooks, Kristy R. ^{[1
]}

Hearst, Emily C. ^{[4
]}

Hess, Steven J. ^{[4
]}

Kudron, Elizabeth L. ^{[1
]}

Lee, Yee Ming ^{[1
,3
]}

Liko, Ina ^{[1
,2
]}

Lowery, Jan ^{[1
]}

Mathias, Rasika A. ^{[1
]}

Monte, Andrew A. ^{[1
]}

Rafaels, Nicholas ^{[1
]}

Rioth, Matthew J. ^{[1
]}

Roberts, Emily R. ^{[1
]}

Taylor, Matthew R. G. ^{[1
]}

Williamson, Connie ^{[4
]}

Barnes, Kathleen C. ^{[1
]}

机构：

[1] Univ Colorado, Sch Med, Colorado Ctr Personalized Med, Aurora, CO 80045 USA

[2] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO 80045 USA

[3] Univ Colorado, Dept Clin Pharm, Skaggs Sch Pharm & Pharmaceut Sci, Aurora, CO 80045 USA

[4] Univ Colorado Hlth, Aurora, CO 80045 USA

来源：

PHARMACOGENOMICS | 2020年 / 21卷 / 06期

关键词：

biobank; implementation; personalized medicine; pharmacogenetics; pharmacogenomics; precision medicine; PERSONALIZED MEDICINE; DECISION-SUPPORT; DESIGN PRINCIPLES; CONSORTIUM; MODEL; PROJECT;

D O I：

10.2217/pgs-2020-0007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, the genomics community has witnessed the growth of large research biobanks, which collect DNA samples for research purposes. Depending on how and where the samples are genotyped, biobanks also offer the potential opportunity to return actionable genomic results to the clinical setting. We developed a preemptive clinical pharmacogenomic implementation initiative via a health system-wide research biobank at the University of Colorado. Here, we describe how preemptive return of clinical pharmacogenomic results via a research biobank is feasible, particularly when coupled with strong institutional support to maximize the impact and efficiency of biobank resources, a multidisciplinary implementation team, automated clinical decision support tools, and proactive strategies to engage stakeholders early in the clinical decision support tool development process.

引用

页码：375 / 386

页数：12

共 37 条

[1]

[Anonymous], 2012, IMPROVING OUTCOMES C

[2] Ten commandments for effective clinical decision support: Making the practice of evidence-based medicine a reality [J].

Bates, DW ;

Kuperman, GJ ;

Wang, S ;

Gandhi, T ;

Kittler, A ;

Volk, L ;

Spurr, C ;

Khorasani, R ;

Tanasijevic, M ;

Middleton, B .

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2003, 10 (06) :523-530

[3] Preemptive Genotyping for Personalized Medicine: Design of the Right Drug, Right Dose, Right Time-Using Genomic Data to Individualize Treatment Protocol [J].

Bielinski, Suzette J. ;

Olson, Janet E. ;

Pathak, Jyotishman ;

Weinshilboum, Richard M. ;

Wang, Liewei ;

Lyke, Kelly J. ;

Ryu, Euijung ;

Targonski, Paul V. ;

Van Norstrand, Michael D. ;

Hathcock, Matthew A. ;

Takahashi, Paul Y. ;

McCormick, Jennifer B. ;

Johnson, Kiley J. ;

Maschke, Karen J. ;

Vitek, Carolyn R. Rohrer ;

Ellingson, Marissa S. ;

Wieben, Eric D. ;

Farrugia, Gianrico ;

Morrisette, Jody A. ;

Kruckeberg, Keri J. ;

Bruflat, Jamie K. ;

Peterson, Lisa M. ;

Blommel, Joseph H. ;

Skierka, Jennifer M. ;

Ferber, Matthew J. ;

Black, John L. ;

Baudhuin, Linnea M. ;

Klee, Eric W. ;

Ross, Jason L. ;

Veldhuizen, Tamra L. ;

Schultz, Cloann G. ;

Caraballo, Pedro J. ;

Freimuth, Robert R. ;

Chute, Christopher G. ;

Kullo, Iftikhar J. .

MAYO CLINIC PROCEEDINGS, 2014, 89 (01) :25-33

[4] Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process [J].

Caudle, Kelly E. ;

Klein, Teri E. ;

Hoffman, James M. ;

Mueller, Daniel J. ;

Whirl-Carrillo, Michelle ;

Gong, Li ;

McDonagh, Ellen M. ;

Sangkuhl, Katrin ;

Thorn, Caroline F. ;

Schwab, Matthias ;

Agundez, Jose A. G. ;

Freimuth, Robert R. ;

Huser, Vojtech ;

Lee, Ming Ta Michael ;

Iwuchukwu, Otito F. ;

Crews, Kristine R. ;

Scott, Stuart A. ;

Wadelius, Mia ;

Swen, Jesse J. ;

Tyndale, Rachel F. ;

Stein, C. Michael ;

Roden, Dan ;

Relling, Mary V. ;

Williams, Marc S. ;

Johnson, Samuel G. .

CURRENT DRUG METABOLISM, 2014, 15 (02) :209-217

[5] Institutional profile: University of Florida Health Personalized Medicine Program [J].

Cavallari, Larisa H. ;

Weitzel, Kristin W. ;

Elsey, Amanda R. ;

Liu, Xinyue ;

Mosley, Scott A. ;

Smith, Donald M. ;

Staley, Benjamin J. ;

Winterstein, Almut G. ;

Mathews, Carol A. ;

Franchi, Francesco ;

Rollini, Fabiana ;

Angiolillo, Dominick J. ;

Starostik, Petr ;

Clare-Salzler, Michael J. ;

Nelson, David R. ;

Johnson, Julie A. .

PHARMACOGENOMICS, 2017, 18 (05) :421-426

[6] A New Initiative on Precision Medicine [J].

Collins, Francis S. ;

Varmus, Harold .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (09) :793-795

[7] Implementing a personalized medicine program in a community health system [J].

Dressler, Lynn G. ;

Bell, Gillian C. ;

Ruch, Karl D. ;

Retamal, Jennifer D. ;

Krug, Paige B. ;

Paulus, Ronald A. .

PHARMACOGENOMICS, 2018, 19 (17) :1345-1356

[8] Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers [J].

Dunnenberger, Henry M. ;

Crews, Kristine R. ;

Hoffman, James M. ;

Caudle, Kelly E. ;

Broeckel, Ulrich ;

Howard, Scott C. ;

Hunkler, Robert J. ;

Klein, Teri E. ;

Evans, William E. ;

Relling, Mary V. .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55, 2015, 55 :89-+

[9] A Practical, Robust Implementation and Sustainability Model (PRISM) for Integrating Research Findings into Practice [J].

Feldstein, Adrianne C. ;

Glasgow, Russell E. .

JOINT COMMISSION JOURNAL ON QUALITY AND PATIENT SAFETY, 2008, 34 (04) :228-243

[10] Evaluating the public health impact of health promotion interventions: The RE-AIM framework [J].

Glasgow, RE ;

Vogt, TM ;

Boles, SM .

AMERICAN JOURNAL OF PUBLIC HEALTH, 1999, 89 (09) :1322-1327

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