Living with the enemy:: a physiological role for the β-amyloid peptide

被引：47

作者：

Esteban, JA ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pharmacol, Ann Arbor, MI 48109 USA

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 01期

关键词：

D O I：

10.1016/j.tins.2003.10.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Abeta peptide, which is derived from the processing of the amyloid precursor protein APP, is the principal agent responsible for the pathogenesis of Alzheimer's disease. In a recent study by Kamenetz et al., Abeta is shown to mediate a physiological homeostatic mechanism that reduces excitatory transmission in response to neuronal activity. Failure of this autoregulatory feedback could lead to the neuropathology of Alzheimer's disease.

引用

页码：1 / 3

页数：3

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