Diverse roles of EV-RNA in cancer progression

被引：21

作者：

Cocks, Alexander ^{[1
]}

Martinez-Rodriguez, Verena ^{[1
,2
]}

Del Vecchio, Filippo ^{[1
]}

Schukking, Monique ^{[1
,3
]}

Broseghini, Elisabetta ^{[1
]}

Giannakopoulos, Stefanos ^{[1
]}

Fabbri, Muller ^{[1
]}

机构：

[1] Univ Hawaii, Canc Biol Program, Canc Ctr, Honolulu, HI 96813 USA

[2] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA

[3] Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2021年 / 75卷

基金：

美国国家卫生研究院;

关键词：

Extracellular vesicles; RNA; Cancer; Tumor microenvironment; microRNAs; Non-Coding RNAs; HORIZONTAL TRANSFER; MEDIATED TRANSFER; CELL-PROLIFERATION; ENDOTHELIAL-CELLS; DENDRITIC CELLS; EXOSOMES; MICRORNAS; PROMOTES; ANGIOGENESIS; TELOMERASE;

D O I：

10.1016/j.semcancer.2020.11.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extracellular vesicles (EVs) have emerged as important players in all aspects of cancer biology. Their function is mediated by their cargo and surface molecules including proteins, lipids, sugars and nucleic acids. RNA in particular is a key mediator of EV function both in normal and cancer cells. This statement is supported by several lines of evidence. First, cells do not always randomly load RNA in EVs, there seems to be a specific manner in which cells populate their EVs with certain RNA molecules. Moreover, cellular uptake of EV-RNA and the secondary compartmentalization of EV-RNA in recipient cells is widely reported, and these RNAs have an impact on all aspects of cancer growth and the anti-tumoral immune response. Additionally, EV-RNA seems to work through various mechanisms of action, highlighting the intricacies of EVs and their RNA cargo as prominent means of inter-cellular communication.

引用

页码：127 / 135

页数：9

共 99 条

[1] Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes [J].

Ahadi, Alireza ;

Brennan, Samuel ;

Kennedy, Paul J. ;

Hutvagner, Gyorgy ;

Nham Tran .

SCIENTIFIC REPORTS, 2016, 6

[2]

Albanese M., 2020, MICRO RNAS ARE MINOR, DOI [10.1101/2020.05.20.106393, DOI 10.1101/2020.05.20.106393]

[3] Radiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles [J].

Ariyoshi, Kentaro ;

Miura, Tomisato ;

Kasai, Kosuke ;

Fujishima, Yohei ;

Nakata, Akifumi ;

Yoshida, Mitsuaki .

SCIENTIFIC REPORTS, 2019, 9 (1)

[4] Biodistribution and function of extracellular miRNA-155 in mice [J].

Bala, Shashi ;

Csak, Timea ;

Momen-Heravi, Fatemeh ;

Lippai, Dora ;

Kodys, Karen ;

Catalano, Donna ;

Satishchandran, Abhishek ;

Ambros, Victor ;

Szabo, Gyongyi .

SCIENTIFIC REPORTS, 2015, 5

[5] Horizontal transfer of oncogenes by uptake of apoptotic bodies [J].

Bergsmedh, A ;

Szeles, A ;

Henriksson, M ;

Bratt, A ;

Folkman, MJ ;

Spetz, AL ;

Holmgren, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (11) :6407-6411

[6] Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes [J].

Berrondo, Claudia ;

Flax, Jonathan ;

Kucherov, Victor ;

Siebert, Aisha ;

Osinski, Thomas ;

Rosenberg, Alex ;

Fucile, Christopher ;

Richheimer, Samuel ;

Beckham, Carla J. .

PLOS ONE, 2016, 11 (01)

[7] miR-1289 and "Zipcode"-like Sequence Enrich mRNAs in Microvesicles [J].

Bolukbasi, Mehmet Fatih ;

Mizrak, Arda ;

Ozdener, Gokhan Baris ;

Madlener, Sibylle ;

Stroebel, Thomas ;

Erkan, Erdogan Pekcan ;

Fan, Jian-Bing ;

Breakefield, Xandra O. ;

Saydam, Okay .

MOLECULAR THERAPY-NUCLEIC ACIDS, 2012, 1

[8] Telomerase and the maintenance of chromosome ends [J].

Bryan, TM ;

Cech, TR .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (03) :318-324

[9] Exosomes of glioma cells deliver miR-148a to promote proliferation and metastasis of glioblastoma via targeting CADM1 [J].

Cai, Qian ;

Zhu, Anding ;

Gong, Li .

BULLETIN DU CANCER, 2018, 105 (7-8) :643-651

[10] Programmed Cell Death 4 and MicroRNA 21 Inverse Expression Is Maintained in Cells and Exosomes From Ovarian Serous Carcinoma Effusions [J].

Cappellesso, Rocco ;

Tinazzi, Andrea ;

Giurici, Thomas ;

Simonato, Francesca ;

Guzzardo, Vincenza ;

Ventura, Laura ;

Crescenzi, Marika ;

Chiarelli, Silvia ;

Fassina, Ambrogio .

CANCER CYTOPATHOLOGY, 2014, 122 (09) :685-693

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