Efficient assembly of an indole alkaloid skeleton by cyclopropanation:: Concise total synthesis of (±)-minfiensine

被引：102

作者：

Shen, Liqun

Zhang, Min

Wu, Ti

Qin, Yong ^{[1
]}

机构：

[1] Sichuan Univ, Dept Chem Med Nat Prod, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Key Lab Drug Targeting, W China Sch Pharm, Chengdu 610041, Peoples R China

[3] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 19期

关键词：

alkaloids; cyclopropanation; minfiensine; tetracyclic skeleton; total synthesis;

D O I：

10.1002/anie.200800566

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Cascading into (±)-minfiensine: An efficient method was developed for the assembly of tetracyclic skeleton 1 by a three-step, one-pot cascade reaction including cyclopropanation, ring opening, and ring closure (see scheme; Ts=p-toluenesulfonyl). The concise total synthesis of the (±)-minfiensine was completed in about a 4% overall yield. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3618 / 3621

页数：4

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