Thermoanalytical, FTIR and X-ray studies of gemfibrozil-cyclodextrin complexes

被引：29

作者：

Aigner, Z

Hassan, HB

Berkesi, O

Kata, M

Eros, I

机构：

[1] Univ Szeged, Dept Pharmaceut Technol, H-6720 Szeged, Hungary

[2] Univ Szeged, Dept Phys Chem, H-6720 Szeged, Hungary

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2005年 / 81卷 / 02期

基金：

匈牙利科学研究基金会;

关键词：

dimethyl-beta-cyclodextrin; DSC; FTIR spectroscopy; gemfibrozil; X-ray diffractometry;

D O I：

10.1007/s10973-005-0777-4

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Inclusion complexation between dimethyl-beta-cyclodextrin and a very poorly water-soluble serum lipid-regulating agent, gemfibrozil, was studied. Products were prepared by several methods (physical mixing, kneading, spray-drying and ultrasonic treatment) in four different molecular ratios (2:1, 1:1, 1:2 and 1:3). The possibility of complex formation between the drug and the host molecule was studied by thermal analysis. Supplementary techniques, such as Fourier transformation-infrared spectroscopy and X-ray diffractometry, were also applied to interpret the results of thermal study of the products.

引用

页码：267 / 272

页数：6

共 23 条

[1] Investigation of tenoxicam and γ-cyclodextrin binary and ternary complexes [J].