MicroRNA biogenesis and regulation of bone remodeling

被引:138
作者
Kapinas, Kristina [1 ]
Delany, Anne M. [1 ]
机构
[1] Univ Connecticut, Ctr Hlth, Ctr Mol Med, Farmington, CT 06030 USA
关键词
OSTEOBLAST DIFFERENTIATION; MESSENGER-RNAS; MORPHOGENETIC PROTEIN-2; EXPRESSION; MECHANISM; TARGET; RUNX2; TRANSLATION; INITIATION; COMPLEX;
D O I
10.1186/ar3325
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression. This review will highlight our current understanding of miRNA biogenesis and mechanisms of action, and will summarize recent work on the role of miRNAs, including the miR-29 family, in bone remodeling. These studies represent the first steps in demonstrating the importance of miRNAs in the control of osteoblast and osteoclast differentiation and function. An in-depth understanding of the roles of these regulatory RNAs in the skeleton will be critical for the development of new therapeutics aimed at treating bone loss and perhaps facilitating fracture repair.
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页数:11
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共 83 条
[1]   The functions of animal microRNAs [J].
Ambros, V .
NATURE, 2004, 431 (7006) :350-355
[2]   Differential regulation of microRNA stability [J].
Bail, Sophie ;
Swerdel, Mavis ;
Liu, Hudan ;
Jiao, Xinfu ;
Goff, Loyal A. ;
Hart, Ronald P. ;
Kiledjian, Megerditch .
RNA, 2010, 16 (05) :1032-1039
[3]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[4]   Mammalian mirtron genes [J].
Berezikov, Eugene ;
Chung, Wei-Jen ;
Willis, Jason ;
Cuppen, Edwin ;
Lai, Eric C. .
MOLECULAR CELL, 2007, 28 (02) :328-336
[5]   Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells [J].
Bhattacharyya, S. N. ;
Habermacher, R. ;
Martine, U. ;
Closs, E. I. ;
Filipowicz, W. .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2006, 71 :513-521
[6]  
Bonewald L.F., 2008, The primer on metabolic bone diseases and disorders of mineral metabolism, V7th, P22
[7]   RNA polymerase III transcribes human microRNAs [J].
Borchert, Glen M. ;
Lanier, William ;
Davidson, Beverly L. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (12) :1097-1101
[8]   The role of SPARC in extracellular matrix assembly [J].
Bradshaw, Amy D. .
JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2009, 3 (3-4) :239-246
[9]   Principles of MicroRNA-target recognition [J].
Brennecke, J ;
Stark, A ;
Russell, RB ;
Cohen, SM .
PLOS BIOLOGY, 2005, 3 (03) :404-418
[10]   Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs [J].
Cai, XZ ;
Hagedorn, CH ;
Cullen, BR .
RNA, 2004, 10 (12) :1957-1966